International Journal of Hematology and Oncology
2024, Vol 34, Num 4 Page(s): 073-079
LUNG CANCER IN YOUNG PATIENTS
ESRA KAYTAN1, E. MERDAN FAYDA1, SEVGİ ÖZDEN1, E. NEZİH ORAL1, AHMET KİZİR1
İstanbul Üniversitesi İstanbul Tıp Fakültesi Radyasyon Onkolojisi Anabilim Dalı
Keywords: lung cancer, younger patients, advanced stage, prognostic factors
The records of 58 patients younger than 35 years of age who had bronchogenic carcinoma diagnosed between 1989-1999 were analyzed for demographic features and prognostic factors. Forty-eight men and 10 women patients had median age of 33 (range: 26-35). Adenocarcinoma was the most frequent (55%) histologic type. The majority of the patients were in the advanced stage (96% stage III and IV) at the time of diagnosis. History of smoking was high (71%),and more frequent in males than in females (84% vs. 10%). LDH level was high in II patients (28%), and anemia under 10 g/dl was present in 13 patients (30%). Overall median survival was 6.7 months; the 2 year survival rate was 12%. In univariate analysis, gender (p=0.01), cigarette smoking (p=0.04), LDH levels (p=0.001), performance status (p=0.0002), and stage (p=0.05) were found as prognostic factors. Performance status (p=0.02) and LDH levels (p=0.02) were statistically significant prognostic factors in multivariate analysis. The patients who had high LDH level a 4.8 fold, and those with <70 performance status a 4.3 fold greater probability of death (95% confidence interval: 4.9-14.5 and 4.9-12.4, respectively). As a result, prognostic factors in lung cancer at young age did not differ from those in elderly. However the frequency of advanced disease at presentation was greater in younger patients.
ESRA KAYTAN1, E. MERDAN FAYDA1, SEVGİ ÖZDEN1, E. NEZİH ORAL1, AHMET KİZİR1
İstanbul Üniversitesi İstanbul Tıp Fakültesi Radyasyon Onkolojisi Anabilim Dalı
Keywords: lung cancer, younger patients, advanced stage, prognostic factors
The records of 58 patients younger than 35 years of age who had bronchogenic carcinoma diagnosed between 1989-1999 were analyzed for demographic features and prognostic factors. Forty-eight men and 10 women patients had median age of 33 (range: 26-35). Adenocarcinoma was the most frequent (55%) histologic type. The majority of the patients were in the advanced stage (96% stage III and IV) at the time of diagnosis. History of smoking was high (71%),and more frequent in males than in females (84% vs. 10%). LDH level was high in II patients (28%), and anemia under 10 g/dl was present in 13 patients (30%). Overall median survival was 6.7 months; the 2 year survival rate was 12%. In univariate analysis, gender (p=0.01), cigarette smoking (p=0.04), LDH levels (p=0.001), performance status (p=0.0002), and stage (p=0.05) were found as prognostic factors. Performance status (p=0.02) and LDH levels (p=0.02) were statistically significant prognostic factors in multivariate analysis. The patients who had high LDH level a 4.8 fold, and those with <70 performance status a 4.3 fold greater probability of death (95% confidence interval: 4.9-14.5 and 4.9-12.4, respectively). As a result, prognostic factors in lung cancer at young age did not differ from those in elderly. However the frequency of advanced disease at presentation was greater in younger patients.