International Journal of Hematology and Oncology 2024, Vol 34, Num 1 Page(s): 055-060
ACK1/TNK2 Tyrosine Kinase Overexpression Role in Gastric Cancer

Ozlem ERCELEP1, Sevinc KESER2, Melike OZCELIK1, Merve BASAR2

1Dr. Lutfi Kirdar Kartal Training and Research Hospital, Department of Medical Oncology, Istanbul, TURKEY
2Dr. Lutfi Kirdar Kartal Training and Research Hospital, Department of Pathology, Istanbul, TURKEY

Keywords: TNK2, ACK1, Gastric cancer, Survival, Overexpression
ACK1 or TNK2 integrate signals from ligand active receptor tyrosine kinases, which are exogenous oncogenic nonreceptor tyrosine kinases, to modulate intracellular signaling cascades 1. Several studies have revealed that ACK1/TNK2 is upregulated in various cancers and promotes tumor progression. This study aimed to determine the prognostic role TNK2 overexpression in gastric cancer. Presence of TNK2 overexpression in pathology blocks of patients with non-metastatic operated gastric cancer was used as prognostic arker and survival was investigated. The pathology samples of 129 patients were studied. Mean survival times (64.2 months) of the gastric cancer patients with TNK2 overexpression were significantly longer than those without overexpression (27.1 months) (p= 0.00). Median follow-up was 39 months. TNK2 overexpression rate was 75% in stage 1-2, 56% in stage 3 (p= 0.027). The positive effect of node negativity, ECOG performance status of 0-1 and TNK2 overexpression on survival in gastric cancer was also shown by multivariate analysis. We identified overexpression of the TNK2 in gastric cancer is correlated with good prognosis.