International Journal of Hematology and Oncology 2024, Vol 34, Num 1 Page(s): 227-238
Immunotherapy for B-acute Lymphoblastic Leukemia by Focusing on Monoclonal Antibody and CAR- T-cell Application

Seyedeh M. MOHAMMADI1, Daryosh M. NEJAD2, Hojjatollah N. CHAROUDEH1

1Tabriz University of Medical Sciences, Stem Cell Research Center, Tabriz, IRAN
2Tabriz University of Medical Sciences, Department of Anatomical Sciences, Tabriz, IRAN

Keywords: Immunotherapy, Lymphoblastic leukemia, Monoclonal antibody
Considerable advances have been made in treatment of acute lymphoblastic leukemia (ALL) with an overall survival rate of 85% in children, and in great improvement in adults. Despite this improvement and the accessibility of hematopoietic stem cell transplantation, relapsed ALL remains a leading cause of childhood mortality emphasizing the need of new approaches on therapy. Leukemia cells express numerous surface antigens amenable to target therapies, consist of CD20, CD22, and CD19. Monoclonal antibodies which target these antigens have improved the outcomes in B-cell ALL. Rituximab is the best known monoclonal antibody which is routinely used in combination with chemotherapy for treatment of adult B-cell ALL. Monoclonal antibodies including unconjugated and conjugated antibodies to cytotoxic agents for treatment of B-cell ALL are now under investigation. In this article we update the results and current status of investigational monoclonal antibody-based therapies in ALL.