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Angiotensin Converting Enzyme (ACE) Insertion/Deletion (I/D) Gene Polymorphisms in Leukemic Hematopoiesis

Ibrahim AKALIN¹, Ebru KOCA², Halil G. KARABULUT¹, Ibrahim C. HAZNEDAROGLU², Deniz CETINER², Mutlu HAYRAN³, Ibrahim K. ONAL⁴, Osman I. OZCEBE², Ajlan TUKUN<sup>1

1</sup>Ankara University Faculty of Medicine, Department of Medical Genetics, Ankara, TURKEY
²Ankara University Faculty of Medicine Department of Internal Medicine, Hematology Unit, Ankara, TURKEY
³Ankara University Faculty of Medicine, Department of Preventive Oncology, Ankara, TURKEY
⁴Hacettepe University Faculty of Medicine, Department of Internal Medicine, Ankara, TURKEY

Keywords: Angiotensin converting enzyme, Local renin-angiotensin system, ACE I/D gene polymorphism, Angiotensin II, Leukemic hematopoiesis

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Local bone marrow renin-angiotensin system (RAS) is an autocrine-paracrine system affecting normal and neoplastic hematopoiesis. Angiotensin converting enzyme (ACE) converts angiotensinogen-I to its physiologically active peptide angiotensin-II, which stimulates proliferation and differentiation of hematopoietic stem cells through angiotensin II type 1 receptors. We investigated the ACE insertion/deletion (I/D) gene polymorphisms in patients with hematological malignancies including acute and chronic leukemia, myelodysplastic syndrome and multiple myeloma. Our results showed that 80.4% of the patients represented ID/II genotype, whereas it was 55.9% of the control group and 3.2 fold increased disease risk in the existence of insertion allele (ID/II). This is the first study demonstrating possible effects of ACE I/D gene polymorphism of the local bone marrow RAS components on leukemic hematopoiesis.

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