International Journal of Hematology and Oncology 2024, Vol 34, Num 1 Page(s): 037-041
The Development of Hodgkin Lymphoma in Male Patient with Systemic Lupus Erythematosus and Secondary Antiphospholipid Syndrome

G. Emel PAMUK1, Ömer N. PAMUK2, Emre TEKGÜNDÜZ1, Burhan TURGUT1, Muzaffer DEMİR1, Necati ÇAKIR2

1Trakya Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Hematoloji Bilim Dalı, EDİRNE
2Trakya Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Romatoloji Bilim Dalı, EDİRNE

Keywords: Systemic lupus erythematosus, Hodgkin’s lymphoma, Lymphadenopathy, Secondary antiphospholipid syndrome
There are some data that the frequency of malignancy increases in some autoimmune diseases. The development of Hodgkin’s lymphoma in patients with systemic lupus erythematosus (SLE) has been reported rarely. Here, we presented a young male SLE patient who had recurrent thrombophlebitis and deep venous thrombosis, secondary antiphospholipids syndrome, and who has been using cyclophosphamide and corticosteroids for 1.5 years for lupus nephritis. After a follow-up of 1.5 years, he developed fever, night sweats and lymphadenopathy. Lymph node biopsy was compatible with mixed-cellular type Hodgkin’s lymphoma, and he was in complete hematologic remission after ABVD chemotherapy. Although SLE is a disease which may cause lymphadenopathy and B symptoms, when these symptoms develop in a SLE patient in remission, lymph node biopsy should be taken to rule out the possibility of lymphoma.