International Journal of Hematology and Oncology
2024, Vol 34, Num 4 Page(s): 165-171
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PATIENTS WIH HODGKIN’S DISEASE : CLINICAL AND PATHOLOGICAL EVALUATION
Abdullah ALTINTAŞ1, Timuçin ÇİL1, M. Ali KAPLAN2, A.Engin ATAY2, Abdurrahman IŞIKDOĞAN1, Hüseyin BÜYÜKBAYRAM3, Orhan AYYILDIZ1, Ekrem MÜFTÜOĞLU1
1Dicle Üniversitesi Tıp Fakültesi İç Hastalıkları-Hematoloji-Onkoloji Bilim Dalı, DİYARBAKIR
2Dicle Üniversitesi Tıp Fakültesi İç Hastalıkları Anabilim Dalı, DİYARBAKIR
3Dicle Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı, DİYARBAKIR
Keywords: Hodgkins’ disease, Lymphoma, Lymphoproliferative disease
Hodgkins’ disease accounts 25% of all lymphoid malignancies and 1% of all cancers. In this study, 150 patients with Hodgkins’ disease were reviewed retrospectively and compared according to age, gender, histopathologic subtype and stage of disease. 102 (68%) of patients were male and 48 (32%) were female with a median age of 41 (16-73) years. The frequencies of histopathological subtypes, mixed cellularity, nodular sclerosis, lymphocyte-rich and lymphocytedepletion, were 63 (42%), 37 (24.6%), 25 (16.6%) and 21 (14%), respectively. Histological subtype was not determined in 4 (2.7%) patients. Distribution of patients according to stages were; 18 (12%) patients were in stage I, 35 (23.3%) patients were in stage II, 52 (34.7%) patients were in stage III and 43 (28.7%) patients were in stage IV. Sufficient staging procedure was not performed in two patients. SPSS 11.0 program was used for statistical analyzes. Patients were divided into two groups; older and younger than 40 years age and no statistical significancy was detected between groups. Also there was no significant relation between histopathological subtype and age. In conclusion; Hodgkin disease predominantly seen in males (M/F: 2.1). Mixed celularity HD was the most frequent subtype and 63.7% of our patients were in advanced stage (stage III ve IV).
Abdullah ALTINTAŞ1, Timuçin ÇİL1, M. Ali KAPLAN2, A.Engin ATAY2, Abdurrahman IŞIKDOĞAN1, Hüseyin BÜYÜKBAYRAM3, Orhan AYYILDIZ1, Ekrem MÜFTÜOĞLU1
1Dicle Üniversitesi Tıp Fakültesi İç Hastalıkları-Hematoloji-Onkoloji Bilim Dalı, DİYARBAKIR
2Dicle Üniversitesi Tıp Fakültesi İç Hastalıkları Anabilim Dalı, DİYARBAKIR
3Dicle Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı, DİYARBAKIR
Keywords: Hodgkins’ disease, Lymphoma, Lymphoproliferative disease
Hodgkins’ disease accounts 25% of all lymphoid malignancies and 1% of all cancers. In this study, 150 patients with Hodgkins’ disease were reviewed retrospectively and compared according to age, gender, histopathologic subtype and stage of disease. 102 (68%) of patients were male and 48 (32%) were female with a median age of 41 (16-73) years. The frequencies of histopathological subtypes, mixed cellularity, nodular sclerosis, lymphocyte-rich and lymphocytedepletion, were 63 (42%), 37 (24.6%), 25 (16.6%) and 21 (14%), respectively. Histological subtype was not determined in 4 (2.7%) patients. Distribution of patients according to stages were; 18 (12%) patients were in stage I, 35 (23.3%) patients were in stage II, 52 (34.7%) patients were in stage III and 43 (28.7%) patients were in stage IV. Sufficient staging procedure was not performed in two patients. SPSS 11.0 program was used for statistical analyzes. Patients were divided into two groups; older and younger than 40 years age and no statistical significancy was detected between groups. Also there was no significant relation between histopathological subtype and age. In conclusion; Hodgkin disease predominantly seen in males (M/F: 2.1). Mixed celularity HD was the most frequent subtype and 63.7% of our patients were in advanced stage (stage III ve IV).
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