International Journal of Hematology and Oncology 2020, Vol 30, Num 3 Page(s): 223-231
The Prognostic Significance of the Expression of Insulin-Like Growth Factor Receptor-I in Prostate Cancer

Aylin F. KORCUM1, Elif TEKELI1, Gamze AKSU1, Gulgun ERDOGAN2, Akif CIFTCIOGLU2

1Akdeniz Üniversitesi Tıp Fakültesi Radyasyon Onkolojisi Anabilim Dalı, TURKEY
2Akdeniz Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı, Antalya, TURKEY

Keywords: Prostate Cancer, Radiotherapy, IGF-IR expression
We aimed to investigate the expression of IGF-IR in prostate cancer and to evaluate their prognostic significance. Between 1999 and 2007, the expression of IGF-IR was investigated by using an immunohistochemical approach in fifty-nine prostate cancer patients who were treated with radiotherapy. Median age was 73 (ranged 56-83) years and median follow up was 48.3 months. Fourty-three patients (73%) were found be IGF-IR positive. Biochemically freedom from relapse free survival was significantly higher in patients with negative stained IGF-IR, age < 70, Gleason score < 8, PSA0 value ≤ 20 ng/ml. Multivariate analysis demonstrated that PSA0 value ≤ 20 ng/ml and PSA2 value ≤0.36 ng/ml were statistically significant predictors of biochemically freedom from relapse free survival. The 4-year overall survival, biochemically freedom from relapse free and distant metastasis free survival were 76%, 80% and 93% respectively. This study demostrated that presence of IGF-IR expression was significantly associated with beter biochemically freedom from relapse free survival rates.