International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 93-98
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Lipid Profile in Jordanian Children with β-thalassemia Major
Kamal M. MANSI1, Talal A. ABURJAI2
1Al al-Bayt University, Faculty of Science, Department of Biological Sciences, JORDAN
2Applied Science University, Faculty of Pharmacy, Department of Medicinal Chemistry and Pharmacognosy, JORDAN
Keywords: β-thalassemia major, Lipid profile, Cholesterol, Triglyceride, High-density lipoprotein, Low-density lipoprotein
The aim of the present study was to investigate the lipid pattern in Jordanian children with Beta-thalassemia major (β-TM). Twenty six transfusion dependent β-TM patients, 14 males and 12 females, (mean age 9 ± 5 years) that undergo periodical blood transfusion and desferioxame as a chelating agent, were studied. Twenty controls of matched age and gender were also included in the study. β-thalassemia major patients showed significantly lower total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol when compared with control. Serum triglycerides levels of TM patients were found to be significantly higher than levels in control subjects. Our results revealed that lipid profile changed in patients with major β-TM. Many factors such as iron overload, liver injury, hormonal disturbances and aging might cause these changes.
Kamal M. MANSI1, Talal A. ABURJAI2
1Al al-Bayt University, Faculty of Science, Department of Biological Sciences, JORDAN
2Applied Science University, Faculty of Pharmacy, Department of Medicinal Chemistry and Pharmacognosy, JORDAN
Keywords: β-thalassemia major, Lipid profile, Cholesterol, Triglyceride, High-density lipoprotein, Low-density lipoprotein
The aim of the present study was to investigate the lipid pattern in Jordanian children with Beta-thalassemia major (β-TM). Twenty six transfusion dependent β-TM patients, 14 males and 12 females, (mean age 9 ± 5 years) that undergo periodical blood transfusion and desferioxame as a chelating agent, were studied. Twenty controls of matched age and gender were also included in the study. β-thalassemia major patients showed significantly lower total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol when compared with control. Serum triglycerides levels of TM patients were found to be significantly higher than levels in control subjects. Our results revealed that lipid profile changed in patients with major β-TM. Many factors such as iron overload, liver injury, hormonal disturbances and aging might cause these changes.
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