IMMUNE RECONSTITUTION AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION IN EARLY POSTTRANSPLANT PERIOD

Teoman  DOĞRU; Fikret  ARPACI; Bekir  ÖZTÜRK; Ali Uğur  URAL; Ferit  AVCU; Alper  SÖNMEZ; Şeref  KÖMÜRCÜ; Ahmet  ÖZET; Aysel  PEKEL; Mustafa  TURAN; Ali  ŞENGÜL

International Journal of Hematology and Oncology 2023, Vol 33, Num 4 Page(s): 009-017

IMMUNE RECONSTITUTION AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION IN EARLY POSTTRANSPLANT PERIOD

Teoman DOĞRU¹, Fikret ARPACI², Bekir ÖZTÜRK², Ali Uğur URAL³, Ferit AVCU³, Alper SÖNMEZ¹, Şeref KÖMÜRCÜ², Ahmet ÖZET², Aysel PEKEL⁴, Mustafa TURAN¹, Ali ŞENGÜL⁴

¹Gülhane School of Medicine Department of Internal Medicine, ANKARA
²Gülhane School of Medicine Department of Medical Oncology, ANKARA
³Gülhane School of Medicine Department of Hematology, ANKARA
⁴Gülhane School of Medicine Department of Immunology, ANKARA

Keywords: Bone marrow transplantation, Immune reconstitution

In this prospective study, the immune reconstitution of the T, B and NK cells, immunoglobulin and complements were investigated in the early posttransplant period of BMT.

Twenty patients (16 male, 4 female; mean age 27.55) were followed up for six months. Peripheral blood samples were obtained on the 14th, 28th, 100th and 180th days.

CD4+ cell count was below the normal till the 180th day. CD8+ cell count showed a rapid increase after the first month and reached to normal at six months. CD4/CD8 ratio was below 1. NK cell count was above the normal during the first 3 months. B cell count was normal. IgA levels were below the normal till the 100th day. IgM levels were normal.

IgG levels showed a significant decline after first month. C3c level were above the normal and C4 level were normal. In conclusion, this study indicates that NK cells show more rapid recovery than the CD8+ and CD19+ cells, while CD4+ cells are still below normal, six months after BMT.