International Journal of Hematology and Oncology 2020, Vol 30, Num 2 Page(s): 212-218

Yaşar HIŞIL1, Fahri ŞAHİN2, Serdar Bedii OMAY3

1Ege Üniversitesi Mühendislik Fakültesi Gıda Mühendisliği, İZMİR
2Ege Üniversitesi Tıp Fakültesi İç Hastalıkları Anabilim Dalı, Hematoloji Bilim Dalı, İZMİR
3Karadeniz Teknik Üniversitesi Tıp Fakültesi Hematoloji Bilim Dalı, TRABZON

Keywords: St.John’s wort, Hypericin, Cancer treatment
The analytical composition of the constituents with major biological interest of herbal drug St. John’s Wort (Hypericum perforatum L.) and their chromatographical analyses and medical importance of extracts are studied in this review. There are many studies about efficacy of St.John’s Wort. Hypericum perforatum is a medicinal plant traditionaly used, both externally and internally, in all Europe for many pathologists. In the last two decades many studies have proved the efficacy of some St.John’s Wort extracts in mild to moderate depression and it has been successful as an antidepresant both in Europe and the US. In recent years increased interest in hypericin which is active constituent of St.John’s Wort, as a potential anticancer agent has arisen since several studies established its power.