International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 086-089
EVALUATION OF PLASMA C-REACTIVE PROTEIN AND D-DIMER LEVELS OF COAL MINERS
AHMET GÜREL1, FERAH ARMUTCU1, MURAT ÜNALACAK1, MUSTAFA AYDIN1, ALİ ÖZEREN1, TEVFİK PINAR1
Karaelmas Üniv. Tıp Fak. Biyokimya AD
Keywords: coal miner, crp, d-dimer
This study was planned to investigate alterations of D-Dimer (DD), which is accepted as an indicator of procoagulant system, and C-reactive protein (CRP), which is accepted as an indicator inlammation in coal miners who were exposed to coal dust. Coal dust increases fibroblast proliferation, extracellular matrix synthesis and secretion of proinflammatory factors. So the effect of coal dust is not restricted to the lungs, but it also affects various systems. Especially its IL6 and TNF-α increasing effect makes us think that coal dust may cause inflammation and alterations in hemodynamic system. In this study, 34 males who had been working in coal mines were taken as study group and 32 males who had not been working in coal mines were taken as control group. CRP and DD levels were studied in blood samples of both groups CRP and DD levels were found to be significantly higher in study group than in control group (p<0.001, p<0.01). As a result, increased levels of DD and CRP indicates that coal miners are under risk of hypercoagulopathy and related thromboembolic complications.
AHMET GÜREL1, FERAH ARMUTCU1, MURAT ÜNALACAK1, MUSTAFA AYDIN1, ALİ ÖZEREN1, TEVFİK PINAR1
Karaelmas Üniv. Tıp Fak. Biyokimya AD
Keywords: coal miner, crp, d-dimer
This study was planned to investigate alterations of D-Dimer (DD), which is accepted as an indicator of procoagulant system, and C-reactive protein (CRP), which is accepted as an indicator inlammation in coal miners who were exposed to coal dust. Coal dust increases fibroblast proliferation, extracellular matrix synthesis and secretion of proinflammatory factors. So the effect of coal dust is not restricted to the lungs, but it also affects various systems. Especially its IL6 and TNF-α increasing effect makes us think that coal dust may cause inflammation and alterations in hemodynamic system. In this study, 34 males who had been working in coal mines were taken as study group and 32 males who had not been working in coal mines were taken as control group. CRP and DD levels were studied in blood samples of both groups CRP and DD levels were found to be significantly higher in study group than in control group (p<0.001, p<0.01). As a result, increased levels of DD and CRP indicates that coal miners are under risk of hypercoagulopathy and related thromboembolic complications.