International Journal of Hematology and Oncology 2020, Vol 30, Num 2 Page(s): 026-032
SERUM LEVELS OF INTERCELLULAR ADHESION MOLECULE 1 (ICAM-1) AND CD 44 IN PEDIATRIC SOLID TUMORS

REJİN KEBUDİ1, İNCİ AYAN1, VİLDAN YASASEVER1, FERHAN AKICI1, ÖMER GÖRGÜN1

İstanbul Üniversitesi, Onkoloji

Keywords: icam-1, cd44, lymphoma, solid tumors
Serum Levels of Intercellular Adhesion Molecule 1 (ICAM-1) and CD 44 in Pediatric Solid Tumors ICAM-1 serves as a ligand for leukocyte integrin adhesion receptors. It mediates granulocyte extravasation, inflammatory processes and immunologic responses. CD 44 is involved in lymphocyte migration and binding. Cellular adhesion molecules have been implicated to have a role in the biologic behaviour and metastatic potential of malignancies. Variation in serum levels of ICAM-1 and CD44 have been reported in some malignancies. The aim of this study is to compare serum levels of ICAM-1 and CD44 in children with solid tumors with levels in healthy children. Levels of ICAM-1 and CD44 were measured by enzyme linked immunosorbent assay (ELISA) in serum samples taken at diagnosis from 66 children with lymphoma (n=28) and other solid tumors (n=38) and from 20 healthy children of similar age, sex and socioeconomic status. ICAM-1 levels of children with non-Hodgkin lymphoma of which 94 % were of B cell were significantly higher than healthy children and children with other malignancies (p<0.0001). Children with Hodgkin lymphoma(p=0.04) and healthy children (p<0.01) had higher serum ICAM-1 levels than those with Ewing sarcoma. Patients with rhabdomyosarcoma (p=0.05) and healthy children (p=0.009) expressed higher serum CD44 levels than patients with non-Hodgkin lymphoma. There was no difference according to stage for ICAM-1 and CD44 levels among patients. In conclusion, high ICAM-1 levels were detected in children with B-cell non-Hodgkin s lymphoma. ICAM-1 levels may be a valuable marker in the follow-up of these patients.