International Journal of Hematology and Oncology 2022, Vol 32, Num 4 Page(s): 171-174
THE FREQUENCY OF CISPLATIN NEPHROTOXICITY AND THE AFFECTING FACTORS IN CHILDREN

YAVUZ KÖKSAL1, GÜLSAN YAVUZ1, MESİHA EKİM1, EMEL ÜNAL1, NURDAN TAÇYILDIZ1, GÜL OFLAZ1, KAZIM SOYLU1, SEVGİ GÖZDAŞOĞLU1, ŞÜKRÜ CİN1

Ankara Üniversitesi Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı

Keywords: cisplatin, carboplatin, nephrotoxicity, urinary beta-2 microglobulin, childhood
Although the most important dose limiting effect of cisplatin is nephrotoxicity, it has been reported that carboplatin which is a cisplatin analogue has less side effects. In our department 12 children with a diagnosis of different solid tumors which had received cisplatin in their chemotherapy protocol and 10 children with retinoblastoma which had received carboplatin in their chemotherapy protocols were examined prospectively. Control group were 15 healthy children. In the group of patients with cisplatin therapy when the total dose 215 mg/m2 was reached serum urea and creatinine levels of 2 patients (18 %) were raised in 4-6th months during the treatment. In one of them acute renal failure was occurred and hemodialysis was needed. When the creatinine clearance level of 11 patients with cisplatin therapy were analysed, we found that creatinine clearance levels of 3 patients ( 27.2 %) began to fall down in 4 - 6th months. In the group who received cisplatin, urine beta-2 microglobuline excretion which shows tubular dysfunction was examined and found that in 5 of the 11 patients (45.5 %), urine beta-2 microglobuline levels began to raised. When compared with healthy children the rise in creatinine concentration according to cisplatin dosage, falling creatinine clearence levels and rise in excretion of beta-2 microglobuline in urine were found statistically important (p< 0.05). In the patients with retinoblastoma who had carboplatin therapy in classical dosage, nephrotoxicity was not observed. These results are found to be similar with the literature.