International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 025-030
INDUCIBLE NITRIC OXIDE EXPRESSION IN BLADDER CANCER
EMİN ÖZBEK 1, BÜLENT MIZRAK 1, MUSTAFA ÖZBEK1, CELALETTİN CAMCI1
Gaziantep University, Department of Urology, GAZİANTEP
Keywords: nitric oxide, inducible nitric oxide, bladder cancer, and immunohistochemistry
Recently it has been shown that nitric oxide (NO) has an important role in the solid tumor growth and invasion. In this article we evaluated inducible nitric oxide synthase (INOS) expression in the superficial and muscle invasive transitional cell carcinoma of the bladder. Tissue sections procured from 30 patients with bladder cancer, 20 superficial and 10 muscle invasive, were studied immunohistochemically and results compared with each other and adjacent normal tissue to the tumor. The expression of INOS was positive in all sections from patients with bladder carcinoma. There was no significant difference between superficial and muscle invasive cancer in terms of INOS positivity, but there was clear relationship between INOS immunoreactivity and tumor grade. INOS expression was detected uniformly negative in the peritumoral histologically normal mucosa the superficial and invasive cancer. Selective INOS expression in the bladder cancer suggest that INOS expression may be used as an immunohistochemical marker, this finding also lead to us INOS may play a significant role in tumor growth and the differentiation.
EMİN ÖZBEK 1, BÜLENT MIZRAK 1, MUSTAFA ÖZBEK1, CELALETTİN CAMCI1
Gaziantep University, Department of Urology, GAZİANTEP
Keywords: nitric oxide, inducible nitric oxide, bladder cancer, and immunohistochemistry
Recently it has been shown that nitric oxide (NO) has an important role in the solid tumor growth and invasion. In this article we evaluated inducible nitric oxide synthase (INOS) expression in the superficial and muscle invasive transitional cell carcinoma of the bladder. Tissue sections procured from 30 patients with bladder cancer, 20 superficial and 10 muscle invasive, were studied immunohistochemically and results compared with each other and adjacent normal tissue to the tumor. The expression of INOS was positive in all sections from patients with bladder carcinoma. There was no significant difference between superficial and muscle invasive cancer in terms of INOS positivity, but there was clear relationship between INOS immunoreactivity and tumor grade. INOS expression was detected uniformly negative in the peritumoral histologically normal mucosa the superficial and invasive cancer. Selective INOS expression in the bladder cancer suggest that INOS expression may be used as an immunohistochemical marker, this finding also lead to us INOS may play a significant role in tumor growth and the differentiation.