International Journal of Hematology and Oncology
2025, Vol 35, Num 2 Page(s): 096-103
| Back | Table of Contents | PDF | Mail to Author | |
Reconfiguration of Lipid Metabolism and SCAP-SREBP Pathway in Endometrial Carcinoma
Najwa DABOUL1, Serife Efsun ANTMEN1, Cem YALAZA2, Ferah TUNCEL3, Hakan AYTAN4, Sema Erden ERTURK5
1Mersin University, Faculty of Pharmacy, Department of Biochemistry
2Baskent University, Faculty of Pharmacy, Department of Biochemistry
3Mersin University, Faculty of Medicine Department of Pathology
4Mersin Univesity, Faculty of Medicine Department of Obstetrics and Gynecology
5Mersin University, Vocational School of Health Services
Keywords: Endometrial cancer, SCAP, SREBP, FASN, SCD
Endometrial cancer (EC), a leading malignancy in women, has seen rising incidence and decreasing age of onset globally, turning it into a significant health concern. Postmenopausal uterine bleeding is a key early sign, enabling prompt diagnosis. EC risk factors include hormonal influences, metabolic disorders, and genetic predispositions. Recent studies have unveiled the vital role of fatty acid metabolism reprogramming in cancer initiation and progression. This research focuses on the gene expression of lipogenesis-related molecules –SREBP cleavage-activating proteins (SCAP), Sterol Regulatory Element Binding Protein (SREBP), Stearoyl-CoA Desaturase (SCD), and Fatty Acid Synthase (FASN)– in endometrial cancer tissues. Using real-time PCR, we analyzed 54 EC patients and 36 healthy controls. The results reveal a significant upregulation of SCAP, SREBPF1, FASN, and SCD in cancerous tissues compared to controls (p< 0.05). Additionally, FASN (p= 0.014) and SCD (p= 0.0001) expression levels were markedly higher in the proliferative phase of controls. These findings highlight the reprogramming of lipid metabolism as a critical driver in EC progression. A deeper understanding of these metabolic pathways could lead to innovative therapies, making lipid metabolism a promising target for future cancer treatments.
Najwa DABOUL1, Serife Efsun ANTMEN1, Cem YALAZA2, Ferah TUNCEL3, Hakan AYTAN4, Sema Erden ERTURK5
1Mersin University, Faculty of Pharmacy, Department of Biochemistry
2Baskent University, Faculty of Pharmacy, Department of Biochemistry
3Mersin University, Faculty of Medicine Department of Pathology
4Mersin Univesity, Faculty of Medicine Department of Obstetrics and Gynecology
5Mersin University, Vocational School of Health Services
Keywords: Endometrial cancer, SCAP, SREBP, FASN, SCD
Endometrial cancer (EC), a leading malignancy in women, has seen rising incidence and decreasing age of onset globally, turning it into a significant health concern. Postmenopausal uterine bleeding is a key early sign, enabling prompt diagnosis. EC risk factors include hormonal influences, metabolic disorders, and genetic predispositions. Recent studies have unveiled the vital role of fatty acid metabolism reprogramming in cancer initiation and progression. This research focuses on the gene expression of lipogenesis-related molecules –SREBP cleavage-activating proteins (SCAP), Sterol Regulatory Element Binding Protein (SREBP), Stearoyl-CoA Desaturase (SCD), and Fatty Acid Synthase (FASN)– in endometrial cancer tissues. Using real-time PCR, we analyzed 54 EC patients and 36 healthy controls. The results reveal a significant upregulation of SCAP, SREBPF1, FASN, and SCD in cancerous tissues compared to controls (p< 0.05). Additionally, FASN (p= 0.014) and SCD (p= 0.0001) expression levels were markedly higher in the proliferative phase of controls. These findings highlight the reprogramming of lipid metabolism as a critical driver in EC progression. A deeper understanding of these metabolic pathways could lead to innovative therapies, making lipid metabolism a promising target for future cancer treatments.
| Back | Table of Contents | PDF | Mail to Author | |