International Journal of Hematology and Oncology 2024, Vol 34, Num 1 Page(s): 057-064
Comparison of Treatment Results and Prognostic Factors of Elderly and Young Patients Receiving Neoadjuvant Chemoradiotherapy in Rectal Cancer

Berrin INANC1, Ozlem MERMUT1

University of Health Sciences, Istanbul Training and Research Hospital, Department of Radiation Oncology, Istanbul, TURKEY

Keywords: Aged, Radiochemotherapy, Rectal neoplasms
In this retrospective research, it was aimed to compared elderly (≤ 65 years) and younger (< 65 years) rectal cancer patients who received neoadjuvant chemoradiotherapy (nCRT) and surgery. A total of 175 local advanced rectal cancer patients were included in this study. 60 elderly patients and 115 younger patients compared prognostic factors, treatment outcomes survival and toxicity between 2 groups of patients. At a median follow-up of 65 months in older patients and 80 months in younger patients.We found that Eastern Cooperative Oncology Groups (ECOG) performance status was significantly different between two groups (p= 0.001). None of the other treatment or patient characteristics differed significantly between the groups. The 5-year overall survival (OS) and disease-free survival (DFS) ratios were 68.0%, 44.7% for older patients and 79.0%, 50.5% for younger patients, respectively. There was no significant difference in DFS (p= 0.311) between the two age groups. However, there was significant difference in OS (p= 0.05) between the two age groups. ECOG of 0–I and ≥ 8-week interval between nCRT and surgery were significant prognostic factors for OS and DFS in the multivariate analyses for both groups Acute haematological toxicitiy, anaemia (58%) and thrombocytopenia (25%) were observed more frequently in elderly patients (p= 0.005). There were no differences in DSF between the older and younger patients, OS rates were lower in the older patient group. A higher rate of acute haematologic toxicity was observed in older patients. However, they had similar tumour responses, treatment outcomes.