International Journal of Hematology and Oncology 2024, Vol 34, Num 1 Page(s): 046-050
Angiotensin Converting Enzyme Insertion/Deletion Gene Polymorphisms in Sudanese Patients with Chronic Lymphocytic Leukaemia

Aisha M. ADAM1, Ibrahim Khidir IBRAHIM1,2, Elshazli Widaa ALI1, Rosline HASSAN2

1Al-Neelain University, Faculty of Medical Laboratory Sciences, Department of Haematology, Khartoum, SUDAN
2Universiti Sains Malaysia, School of Medical Sciences, Department of Haematology, Health Campus, Kerian, Kelantan, MALAYSIA

Keywords: ACE I/D polymorphism, CLL
The aim of this study was to investigate the association between Angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism and the risk of chronic lymphocytic leukaemia (CLL) in Sudanese patients. We present a case control study that includes 40 Sudanese patients with CLL. Among them, 31 (62%) were male and 19 (38%) were female. In addition, 40 subjects who were healthy, were included as a control group. Among them, 19 (47.5%) male and 21 (52.5%) female). Molecular analysis showed that the most frequent genotype in CLL patients was I/I, followed by genotypes D/I and D/D. In the control group, D/D was the most frequent genotype, followed by I/D. The I/I genotype was absent. Our data suggested that a significant association was found between ACE I/D polymorphism and CLL among Sudanese patients.