International Journal of Hematology and Oncology
2025, Vol 35, Num 1 Page(s): 115-119
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Lymphoepithelioma-like Carcinoma of the Breast: A Case Report and Review of the Literature
Betul B. KUCUKZEYBEK1, Hakan POSTACI1, Alp OZGUZER1, Savas YAKAN2, Ali G. DENECLI2
1İzmir Bozyaka Eğitim ve Araştırma Hastanesi Patoloji Bölümü, Izmir, TURKEY
2İzmir Bozyaka Eğitim ve Araştırma Hastanesi 1. Genel Cerrahi Kliniği, Izmir, TURKEY
Keywords: Breast, Lymphoepithelyoma-like carcinoma , Differential diagnosis
Lymphoepithelioma-like carcinoma (LELC) is an undifferantiated carcinoma, which occurs in the organs that exclude nasopharynx, has the same morphologic features with nasofarengeal lymphoepithelioma. LELC has been described in several organs however it is rarely seen in the breast. Due to the undifferentiated appearance of neoplastic cells and the presence of prominent lymphocytic infiltrate, LELC can wrongly be diagnosed as lymphoma and medullary carcinoma. In this case present the LELC of the breast in a 58 year-old woman with clinical, histological and immunohistochemical features with differential diagnosis. It is discussed with the relevant literature.
Betul B. KUCUKZEYBEK1, Hakan POSTACI1, Alp OZGUZER1, Savas YAKAN2, Ali G. DENECLI2
1İzmir Bozyaka Eğitim ve Araştırma Hastanesi Patoloji Bölümü, Izmir, TURKEY
2İzmir Bozyaka Eğitim ve Araştırma Hastanesi 1. Genel Cerrahi Kliniği, Izmir, TURKEY
Keywords: Breast, Lymphoepithelyoma-like carcinoma , Differential diagnosis
Lymphoepithelioma-like carcinoma (LELC) is an undifferantiated carcinoma, which occurs in the organs that exclude nasopharynx, has the same morphologic features with nasofarengeal lymphoepithelioma. LELC has been described in several organs however it is rarely seen in the breast. Due to the undifferentiated appearance of neoplastic cells and the presence of prominent lymphocytic infiltrate, LELC can wrongly be diagnosed as lymphoma and medullary carcinoma. In this case present the LELC of the breast in a 58 year-old woman with clinical, histological and immunohistochemical features with differential diagnosis. It is discussed with the relevant literature.
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