International Journal of Hematology and Oncology 2023, Vol 33, Num 4 Page(s): 100-105
Treatment Effect of Clofibrate in Jaundiced Low Birth Weight Neonates

Ashraf MOHAMMADZADEH1, Ahamad S. FARHAT1, Rana AMİRİ2, Habibollah ESMAELY3, Sepide BAGHERİ1

1Mashhad University Faculty of Medicine, Neonatal Research Center
2Mashhad University Faculty of Nursing and Midwifery
3Mashhad University Faculty of Medicine, Neonatal Research Center, Mashhad, IRAN

Keywords: Klofibrat, Hiperbilirubinemi, Düşük doğum ağırlıklı yenidoğanlar, Tedavi
In this study we determined the treatment effect of clofibrate in low birth weight neonate with hyperbilirubinemia. In a randomized double blind placebo - controlled study, 60 low birth weight neonates who were jaundiced and had hyperbilirubinemia were selected. The treatment group received a single oral dose of clofibrate (100 mg/kg) and the control group received sterile water as placebo. Also both group received Phototherapy in addition of the treatment. Serum bilirubin level was measured at entrance to study and 12, 24, 48 and 72 hours of study. Serum bilirubin decreased in 72 hours in clofibrate group that it was nearly significant (p= 0.061), but there were no significant difference between two groups in 12, 24, 48 hours of study (p= 0.7, p= 0.22, p= 0.19 respectively). Duration of phototherapy in clofibrate group was significantly shorter than control group (p= 0.023). Based on physical exam and liver function tests no side effects were seen.

Our result showed that there wasn’t significant difference between two groups after administration of single dose of clofibrate (100 mg/ kg) in 12, 24, 48 and 72 hour. Although effect of clofibrate on treatment of jaundice wasn't significant between two groups, duration of phototherapy has been decreased significantly in clofibrate groups.