International Journal of Hematology and Oncology 2023, Vol 33, Num 3 Page(s): 031-036
The Role of Radiotherapy in the Management of Patients with Aggressive Fibromatosis

Yasemin BÖLÜKBAŞI1, Serra KAMER1, Yavuz ANACAK1, Arif ARAS1

Ege Üniversitesi Tıp Fakültesi Radyasyon Onkolojisi Anabilim Dalı

Keywords: Aggressive fibromatosis, Radiotherapy, Desmoid tumor
Radiotherapy is one of the effective treatments for aggressive fibromatosis. Between January 1991 to December 2005, 24 patients with aggressive fibromatosis were treated by external radiotherapy at Ege University Medical School Department of Radiation Oncology and the data were analyzed retrospectively. Ten patients were men and 14 patients were women. The localization of the tumor was chest wall in 12 patients and extremity in 12 patients. Fourteen patients had recurrent disease before radiotherapy. Six patients were received adjuvant radiotherapy after the first-line surgery, two patients were referred for neoadjuvant and two were for curative radiotherapy. Within median 62 months (range 5-144) follow up, three patients developed local recurrences. One of them underwent salvage surgery, two had received medical treatment as tamoxifen. One of the patients who received neoadjuvant radiotherapy, tumor could not been detected in pathological specimen. Type of the surgery and margin status have an influence on the response of radiotherapy . Five year local recurrence free survival rate was %81.

For aggressive fibromatosis, radiotherapy could be used effectively for adjuvant, neoadjuvant or curative intent.