International Journal of Hematology and Oncology
2025, Vol 35, Num 1 Page(s): 199-204
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THE ROLE OF SPLENIC RADIATION THERAPY IN SYMPTOMATIC SPLENOMEGALY RELATED TO POLYCYTHAEMIA VERA: A CASE REPORT AND REVIEW OF THE LITERATURE
Diclehan ÜNSAL1, Eda YİRMİBEŞOĞLU1, Suna Ö. OKTAR2, Sema KARAKUŞ3, Yücel PAK1
1Gazi Üniversitesi Tıp Fakültesi Radyasyon Onkolojisi Anabilim Dalı, ANKARA
2Gazi Üniversitesi Tıp Fakültesi Radyoloji Anabilim Dalı, ANKARA
3Başkent Üniversitesi Hematoloji Bilim Dalı, ANKARA
Keywords: Polycythaemia vera, Splenomegaly, Splenic radiation therapy
Chronic myeloproliferative diseases are clonal progenitor cell disorders related to myeloid cell proliferation. In these diseases, splenomegaly is frequently experienced and is the finding that challenges the treatment due to progression. Splenic radiation therapy is the treatment modality for palliation of symptoms. A 63 year old male patient who had been diagnosed as polycythaemia vera, has been treated with splenic radiation therapy due to progression in splenomegaly accompanied with pain and symptomatic thrombocytopenia despite myelosupressive treatment. With 2 fractions per week, with shrinking fields and increasing dose in each week, pain and abdominal fullness related to splenomegaly and splenic infarcts have been palliated. Splenic radiation therapy has been suggested to be kept in mind as an alternative to cytotoxic chemotherapy and surgery in chronic myeloproliferative diseases with massive splenomegaly.
Diclehan ÜNSAL1, Eda YİRMİBEŞOĞLU1, Suna Ö. OKTAR2, Sema KARAKUŞ3, Yücel PAK1
1Gazi Üniversitesi Tıp Fakültesi Radyasyon Onkolojisi Anabilim Dalı, ANKARA
2Gazi Üniversitesi Tıp Fakültesi Radyoloji Anabilim Dalı, ANKARA
3Başkent Üniversitesi Hematoloji Bilim Dalı, ANKARA
Keywords: Polycythaemia vera, Splenomegaly, Splenic radiation therapy
Chronic myeloproliferative diseases are clonal progenitor cell disorders related to myeloid cell proliferation. In these diseases, splenomegaly is frequently experienced and is the finding that challenges the treatment due to progression. Splenic radiation therapy is the treatment modality for palliation of symptoms. A 63 year old male patient who had been diagnosed as polycythaemia vera, has been treated with splenic radiation therapy due to progression in splenomegaly accompanied with pain and symptomatic thrombocytopenia despite myelosupressive treatment. With 2 fractions per week, with shrinking fields and increasing dose in each week, pain and abdominal fullness related to splenomegaly and splenic infarcts have been palliated. Splenic radiation therapy has been suggested to be kept in mind as an alternative to cytotoxic chemotherapy and surgery in chronic myeloproliferative diseases with massive splenomegaly.
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