International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 008-011
CD44V6 EXPRESSION IN NON-HODGKIN'S LYMPHOMAS
CENGİZ CEYLAN1, FATİH DEMİRKAN1, HAYRİ ÖZSAN1, FATİH KUYUCUOĞLU1, MEHMET ALİ ÖZCAN1, BÜLENT ÜNDAR1
Dokuz Eylül University School of Medicine, Division of Hematology-Oncology, İZMİR
Keywords: nonhodgkin lymphoma, cd44v6, international prognostic index
Although international prognostic index (IPI) has been shown to be useful in all grades of lymphomas there is a need to identify biological variables which may more directly help to determine prognostic subgroups. We investigated the immunostaining of CD44v6, a variant form of CD44 adhesion molecule, in 38 patients with the diagnosis of non-Hodgkin's lymphoma (NHL). High/intermediate grade lymphomas expressed CD44v6 more than low grade lymphomas. CD44v6 expression were higher in patients with IPI score >3(p<0.05) in comparison to patients with IPI<2. We couldn't find any statistical significance between CD44v6 expression and Ann Arbor staging, lactate dehydrogenase (LDH) levels, disease relapse and progression, number of extranodal sites, hemoglobin level. Age over 60 and B symptoms correlated with CD44v6 expression. Expression of adhesion molecules such as CD44 variants in lymphomas may have an important role in determining of prognosis.
CENGİZ CEYLAN1, FATİH DEMİRKAN1, HAYRİ ÖZSAN1, FATİH KUYUCUOĞLU1, MEHMET ALİ ÖZCAN1, BÜLENT ÜNDAR1
Dokuz Eylül University School of Medicine, Division of Hematology-Oncology, İZMİR
Keywords: nonhodgkin lymphoma, cd44v6, international prognostic index
Although international prognostic index (IPI) has been shown to be useful in all grades of lymphomas there is a need to identify biological variables which may more directly help to determine prognostic subgroups. We investigated the immunostaining of CD44v6, a variant form of CD44 adhesion molecule, in 38 patients with the diagnosis of non-Hodgkin's lymphoma (NHL). High/intermediate grade lymphomas expressed CD44v6 more than low grade lymphomas. CD44v6 expression were higher in patients with IPI score >3(p<0.05) in comparison to patients with IPI<2. We couldn't find any statistical significance between CD44v6 expression and Ann Arbor staging, lactate dehydrogenase (LDH) levels, disease relapse and progression, number of extranodal sites, hemoglobin level. Age over 60 and B symptoms correlated with CD44v6 expression. Expression of adhesion molecules such as CD44 variants in lymphomas may have an important role in determining of prognosis.