International Journal of Hematology and Oncology 2019, Vol 29, Num 2 Page(s): 079-087
Pretreatment Inflammatory Indexes are Associated with Response to First-Line Platinum- Based Chemotherapy and Prognosis of Small Cell Lung Cancer Patients

Mevlude INANC1, Oktay BOZKURT1, Ayse OCAK DURAN2, Metin OZKAN1, Mustafa ALTINBAS3

1Erciyes University Faculty of Medicine. Department of Medical Oncology, Kayseri TURKEY
2Ankara Oncology Training and Research Hospital. Department of Medical Oncology, Ankara TURKEY
3Diskapi Yildirim Beyazid Education and Research Hospital. Department of Medical Oncology, Ankara TURKEY

Keywords: Small cell lung cancer, Neutrophil-to-lymphocyte ratio, Platelet-to-lymphocyte ratio, Prognosis
The immune system plays an important role in the progression of the cancer. Some studies have shown that neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are prognostic indicators in many cancers. In this study we investigated the whether NLR and PLR predicts survival of small cell lung cancer (SCLC). 177 SCLC patients treated with Cisplatin + Etoposide chemotherapy were admitted to the study. After third cycle of chemotherapy the response was evaluated clinically and radiologically and randomized into 2 groups based on responses to chemotherapy; Progressive disease group (PD) or Response group (Complete Response+ Partial response+ Stable Disease). A NLR ≥ 5 was considered high. There was no difference between the two groups in terms of the initial NLR; however control NLR values were different. NLR values were significantly decreased after chemotherapy for both groups when compared to baseline values in determining intra-group analyzing (for PD group p= 0.05; for Response group p= 0.013). NLR value < 5 patient group had longer overall survival than NLR ≥ 5 patient group (10 vs. 7 months; p= 0.015). Age. NLR. smoking. ECOG PS 2 and stage were independent prognostic factor for overall survival (OS) (respectively; p< 0.001. p= 0.006. p= 0.05. p= 0.02. p= 0.03). but PLR was not independent prognostic factor for OS. In this study. we evaluated the relationship between NLR and SCLC. and found that NLR is a potential prognostic serum marker in patients with SCLC. Also current smoking. aging. poor performance status and extensive disease are prognostic factors in SCLC patients.