International Journal of Hematology and Oncology 2018, Vol 28, Num 3 Page(s): 001-007
Does Lapatinib Increase Pulmonary Toxicity when Concurrently Used with Radiation Therapy? An Experimental Study with Wistar-Albino Rats

Ozlem YETMEN DOGAN1, Elif GUZEL2, Ilker COBAN1, Oner SUZER4, Nuran BESE5

1Saglik Bilimleri University, Kartal Dr. Lutfi Kirdar Training and Research Hospital, Department of Radiation Oncology, Istanbul,TURKEY
2Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Histology and Embryology, Istanbul,TURKEY
3Yeditepe University, Faculty of Medicine, Department of Physiology, Istanbul,TURKEY
4Istanbul University-Cerrapaşa, Cerrahpasa Faculty of Medicine, Department of Medical Pharmacology, Istanbul,TURKEY
5Acıbadem University, Acıbadem Maslak Hospital, Department of Radiation Oncology, Istanbul,TURKEY

Keywords: Breast cancer, Lapatinib, Radiotherapy, Wistar-albino rats, Animal study
Lapatinib is an oral receptor tyrosine kinase inhibitor which has shown activity in the treatment of metastatic breast cancer. There is
no data regarding the side effects of combination of radiotherapy and Lapatinib. 40 female Wistar-albino rats (WAR) were divided into
4 groups; G1 did not receive any treatment, G2 received radiotherapy to whole thoracic region, G3 received Lapatinib without radiotherapy,
G4 received Lapatinib with radiotherapy. A total dose of 30 Gy in 10 fractions was given to both lungs. Lapatinib equivalent
to 1500 mg/day were calculated according to the mean weight of rats, orally administrated. A comparative analysis was performed
by scoring the pulmonary injury between 0 and 3 according to the infiltration of inflammatory cells into the alveolar spaces, alveolar
wall thickening and architectural deformation across the entire lung section. In G2 inflammatory cell infiltration, fibrosis with damage
to lung structure andformation of small fibrous masses were observed. Alveolar septa were significantly thicker than G1 (p≤ 0.001),
which revealed totally normal pulmonary structure. G3 showed minimal alveolar septal thickening and infiltration of inflammatory cells
into the alveolar spaces which was not significantly different than G1. Histopathological findings in G4 were similar to those in G2 and
statistically different when compared with the G1 and G3 (p≤ 0.001). In this experimental study it has been shown that addition of
Lapatinib to radiation did not increase RIPF in rats.