International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 123-129
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Association of CD14 -159 Gene Polymorphism with Characteristics and Outcome of Diffuse Large B-cell Lymphomas
Lavinika ATANASKOVIC1, Olivera TARABAR1, Zvonko MAGIC2, Dragana STAMATOVIC1, Andjelina ZIVANOVIC1, Slobodan MARJANOVIC1, Bojana CIKOTA-ALEKSIC2
1Military Medical Academy, Clinic of Hematology, Belgrade, SERBIA
2Military Medical Academy, Institute of Medical Research, Belgrade, SERBIA
Keywords: Diffuse large B-cell lymphoma, CD14, Genotyping
The aim of this study was to assess the association between CD14 -159 genotypes and DLBCL characteristics, clinical course and outcome, respectively. The study included 114 patients with the newly diagnosed DLBCL. All patients received R-CHOP therapy (6-8 cycles). CD14 -159C→T genotyping was performed by using PCR RFLP. Obtained frequencies of CD14 -159 genotypes were as follows: 23% of CC, 41% of CT and 36% of TT. Statistically significant association between CD14 genotypes and clinical characteristics (age, sex, disease stage, extranodal sites, bulky disease, IPI, lymphocyte and lymphocyte/monocyte count) was found only for extranodal disease (p= 0.01). CT/TT carriers more frequently presented extranodal disease (OR 3.191, 95% CI: 1.282-7.94). In addition, these patients had higher pretreatment values of CRP (p= 0.078). During the therapy, -infections (p= 0.083), and earlytreatment- related complications (p= 0.079) were more commonly present in carriers of CC genotype. In patients with extranodal DLBCL, TT genotype was associated with superior OS (p= 0.049) and RFS, (p=0.018). Multivariate analysis revealed IPI (HR 2.422, 95% CI 1.114-5.264; p= 0.026) and CD14 TT genotype (HR 0.503, 95% CI: 0.262 – 0.963; p= 0.038) as the most prominent factors for OS. Our study reveals the association of CD14-159 T allele with the presence of extranodal DLBCL and elevated CRP level at diagnosis. However, during the treatment T allele manifested protective role since patients with CT/TT genotypes less frequently experienced infections and early-treatment-related complications. In addition, TT genotype was associated with improved survival, but only in patients with extranodal disease.
Lavinika ATANASKOVIC1, Olivera TARABAR1, Zvonko MAGIC2, Dragana STAMATOVIC1, Andjelina ZIVANOVIC1, Slobodan MARJANOVIC1, Bojana CIKOTA-ALEKSIC2
1Military Medical Academy, Clinic of Hematology, Belgrade, SERBIA
2Military Medical Academy, Institute of Medical Research, Belgrade, SERBIA
Keywords: Diffuse large B-cell lymphoma, CD14, Genotyping
The aim of this study was to assess the association between CD14 -159 genotypes and DLBCL characteristics, clinical course and outcome, respectively. The study included 114 patients with the newly diagnosed DLBCL. All patients received R-CHOP therapy (6-8 cycles). CD14 -159C→T genotyping was performed by using PCR RFLP. Obtained frequencies of CD14 -159 genotypes were as follows: 23% of CC, 41% of CT and 36% of TT. Statistically significant association between CD14 genotypes and clinical characteristics (age, sex, disease stage, extranodal sites, bulky disease, IPI, lymphocyte and lymphocyte/monocyte count) was found only for extranodal disease (p= 0.01). CT/TT carriers more frequently presented extranodal disease (OR 3.191, 95% CI: 1.282-7.94). In addition, these patients had higher pretreatment values of CRP (p= 0.078). During the therapy, -infections (p= 0.083), and earlytreatment- related complications (p= 0.079) were more commonly present in carriers of CC genotype. In patients with extranodal DLBCL, TT genotype was associated with superior OS (p= 0.049) and RFS, (p=0.018). Multivariate analysis revealed IPI (HR 2.422, 95% CI 1.114-5.264; p= 0.026) and CD14 TT genotype (HR 0.503, 95% CI: 0.262 – 0.963; p= 0.038) as the most prominent factors for OS. Our study reveals the association of CD14-159 T allele with the presence of extranodal DLBCL and elevated CRP level at diagnosis. However, during the treatment T allele manifested protective role since patients with CT/TT genotypes less frequently experienced infections and early-treatment-related complications. In addition, TT genotype was associated with improved survival, but only in patients with extranodal disease.
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