International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 253-259
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Acute in Vitro effects of ABS (Ankaferd Hemostat) on the Lymphoid Neoplastic Cells (B-CLL and RAJI Tumor Cell Lines)
Ibrahim AKALIN1,2, Fatma V. OKUR2,3, Ibrahim C. HAZNEDAROGLU3, Nilgun SAYINALP3, Salih AKSU3, Yahya BUYUKASIK3, Hakan GOKER3
1Istanbul Medeniyet University Faculty of Medicine, Department of Medical Genetics, Istanbul, TURKEY
2Baylor College of Medicine, Center for Cell and Gene Therapy, Houston, Texas, USA
3Hacettepe University Faculty of Medicine, Department of Hematology, Ankara, TURKEY
Keywords: Ankaferd,Hemostasis, Neoplastic bleeding,Tumor cell lines
ABS (Ankaferd Hemostat) has emerged as a novel haemostatic agent of plant origin. Its ability to interact with entire proteins including cell surface receptors and/or blood proteins plus tissue proteins revealed novel functions of ABS to biologic systems especially tumor associated transcription factors. Thus, in our study, we aimed to investigate the effects of ABS on lymphoid neoplastic cells in vitro. We showed that Ankaferd treated B-CLL cells (at doses 0.5, 1 and 2 μg/mL) ceased to inflate and more than 50% of tumor cells were died compared to 0.1 and 0.25 μg/mL doses. Additionally, transformation of B-CLL cells to the blastic aggressive lymphoid forms was prevented by addition of Ankaferd to culture medium. The results have given the clues of anti-neoplastic effects at higher doses (>0.5 μg/mL) and induction of cellular differentiation at lower doses (<0.5 μg/mL) and proposed future advances in treatment of neoplastic bleedings.
Ibrahim AKALIN1,2, Fatma V. OKUR2,3, Ibrahim C. HAZNEDAROGLU3, Nilgun SAYINALP3, Salih AKSU3, Yahya BUYUKASIK3, Hakan GOKER3
1Istanbul Medeniyet University Faculty of Medicine, Department of Medical Genetics, Istanbul, TURKEY
2Baylor College of Medicine, Center for Cell and Gene Therapy, Houston, Texas, USA
3Hacettepe University Faculty of Medicine, Department of Hematology, Ankara, TURKEY
Keywords: Ankaferd,Hemostasis, Neoplastic bleeding,Tumor cell lines
ABS (Ankaferd Hemostat) has emerged as a novel haemostatic agent of plant origin. Its ability to interact with entire proteins including cell surface receptors and/or blood proteins plus tissue proteins revealed novel functions of ABS to biologic systems especially tumor associated transcription factors. Thus, in our study, we aimed to investigate the effects of ABS on lymphoid neoplastic cells in vitro. We showed that Ankaferd treated B-CLL cells (at doses 0.5, 1 and 2 μg/mL) ceased to inflate and more than 50% of tumor cells were died compared to 0.1 and 0.25 μg/mL doses. Additionally, transformation of B-CLL cells to the blastic aggressive lymphoid forms was prevented by addition of Ankaferd to culture medium. The results have given the clues of anti-neoplastic effects at higher doses (>0.5 μg/mL) and induction of cellular differentiation at lower doses (<0.5 μg/mL) and proposed future advances in treatment of neoplastic bleedings.
| Back | Table of Contents | Turkish Abstract | PDF | Mail to Author | |