International Journal of Hematology and Oncology 2023, Vol 33, Num 4 Page(s): 095-099
ACUTE DEMYELINATING ENCEPHALOMYELITIS DUE TO CISPLATIN: CASE REPORT

FAHRİ ŞAHİN1, GÜRAY SAYDAM1, K. PINAR ÖZEN1, FİKRET BADEMKIRAN1, FİLİZ BÜYÜKKEÇECİ1

Ege Üniversitesi Tıp Fakültesi İç Hastalıkları AD, Hematoloji BD

Keywords: cisplatin, acute demyelinating encephalomyelitis, non-hodgkin lymphoma
Cisplatin is an anticancer agent which is mostly used in the treatment of broad range cancers including ovarian, breast, testicular cancers, non-small cell lung cancer and, head-neck cancers. It is also used in the treatment of hematological malignancies, especially in non-Hodgkin Lymphomas, with combination of other anti-malignant drugs. Neurological side effects of cisplatin is dose-limiting and consist of peripheral sensorial neuropathy, ototoxicity, rarely autonomous neuropathy and, Lhermitte sign, retrobulber neurit and retinal toxicity. Temporary blindness and necrotising leuko-encephalomyopathy are very rare complications in the cisplatin treatment. We here reported the case with non-Hodgkin Lymphoma treated with cisplatin including combination regimen. During the follow-up period, acute demyelinating encephalomyelitis was detected with MRI scanning caused by cisplatin. We interrupted the treatment and the patient died due to septic shock after one month of detection of neurological side effects.