International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 036-044
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The Effects of Royal Jelly Against Radiation-Induced Acute Oral Mucositis
Yasemin B. CIHAN1, Kemal DENIZ2
1Kayseri Education and Research Hospital, Department of Radiation Oncology, Kayseri, TURKEY
2Erciyes University Medical School, Department of Pathology, Kayseri, TURKEY
Keywords: Radiotherapy, Oral mucositis, Royal jelly, Rat, Antioxidant
The purpose of this study was to investigate the effects of royal jelly against radiation-induced oral mucositis in rats. This study was comprised of 48 adult male Sprague-Dawley rats, each between eight and 12 weeks old and weighing 275±35 g. These were divided randomly into six groups; Group C (control), Group IR (irradiation), Group IR+RJ50 (irradiation plus 50 mg/kg royal jelly), Group IR+RJ100 (irradiation plus 100 mg/kg royal jelly), Group RJ50 (50 mg/kg royal jelly), and Group RJ100 (100 mg/kg royal jelly). The degree of mucositis, the animal’s body mass, and food intake were evaluated. Biochemical and histopathological methods were utilized for the evaluation of mucositis, and a hemogram, oxidative stress markers, and biochemical parameters were analyzed. Tongue samples were also processed for histopathological examination. Irradiation significantly increased oral mucositis, decreased the thrombocyte and neutrophil counts, and resulted in a reduction of food intake accompanied by weight loss. In addition, a significant increase in malondialdehyde (MDA) levels and decreased superoxide dismutase (SOD) and catalase (CAT) activities were found (p< 0.001). Irradiation plus 50 mg/kg royal jelly caused normalization in the quantitative, biochemical, and histopathological parameters compared with the group that underwent irradiation alone. Irradiation plus 100 mg/kg royal jelly did not provide superior radioprotection against radiation-induced toxicities. Royal jelly was administered orally to reduce oral mucositis as it may be more suitably applied.
Yasemin B. CIHAN1, Kemal DENIZ2
1Kayseri Education and Research Hospital, Department of Radiation Oncology, Kayseri, TURKEY
2Erciyes University Medical School, Department of Pathology, Kayseri, TURKEY
Keywords: Radiotherapy, Oral mucositis, Royal jelly, Rat, Antioxidant
The purpose of this study was to investigate the effects of royal jelly against radiation-induced oral mucositis in rats. This study was comprised of 48 adult male Sprague-Dawley rats, each between eight and 12 weeks old and weighing 275±35 g. These were divided randomly into six groups; Group C (control), Group IR (irradiation), Group IR+RJ50 (irradiation plus 50 mg/kg royal jelly), Group IR+RJ100 (irradiation plus 100 mg/kg royal jelly), Group RJ50 (50 mg/kg royal jelly), and Group RJ100 (100 mg/kg royal jelly). The degree of mucositis, the animal’s body mass, and food intake were evaluated. Biochemical and histopathological methods were utilized for the evaluation of mucositis, and a hemogram, oxidative stress markers, and biochemical parameters were analyzed. Tongue samples were also processed for histopathological examination. Irradiation significantly increased oral mucositis, decreased the thrombocyte and neutrophil counts, and resulted in a reduction of food intake accompanied by weight loss. In addition, a significant increase in malondialdehyde (MDA) levels and decreased superoxide dismutase (SOD) and catalase (CAT) activities were found (p< 0.001). Irradiation plus 50 mg/kg royal jelly caused normalization in the quantitative, biochemical, and histopathological parameters compared with the group that underwent irradiation alone. Irradiation plus 100 mg/kg royal jelly did not provide superior radioprotection against radiation-induced toxicities. Royal jelly was administered orally to reduce oral mucositis as it may be more suitably applied.
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