International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 242-249
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Influence of GSTM1, GSTP1, and GSTT1 Gene Polymorphisms on Prostate Cancer Risk in Turkish Population
Ufuk BERBER1, Ismail YILMAZ1, Omer YILMAZ2, Aptullah HAHOLU1, Zafer KUCUKODACI1, Ferhat ATES2, Dilaver DEMIREL1
1GATA Haydarpasa Training Hospital, Department of Pathology, TURKEY
2GATA Haydarpasa Training Hospital, Department of Urology, Ankara, TURKEY
Keywords: Prostate cancer, GSTM1, GSTP1, GSTT1, Polymorphism
We analysed glutathione S-transferase M1, T1, and P1 gene polymorphisms in a case control study to asses their susceptibility to prostate cancer in Turkish population. Polymorphisms were determined by PCR-based methods in 115 control subjects and 115 prostate cancer patients. The frequencies of polymorphisms were compared between patients and controls by logistic regression analysis. Possible associations of genetic profiles with respect to the Gleason score and patient age were also investigated. Besides GSTT1 null genotype has slightly increased prostate cancer risk (odds ratio(OR) = 1.50, 95% confidence interval (CI), 0.85-2.66), its association with prostate cancer risk was statistically significant among smokers (OR = 3.20, 95%CI, 1.06-9.70). GSTP1 Val/Val genotype was more common in cancer patients (OR = 1.63, 95%CI, 0.61-4.37). However, the combination of GSTP1 Ile/Ile and GSTT1 null genotype was associated with a higher risk (OR = 2.67, 95%CI, 1.00-7.10). Our results suggest that GSTT1 null genotype may modify prostate cancer risk among cigarette smokers seperately, and in combination with GSTP1 Ile/Ile genotype, irrespective of the smoking habit in Turkish population.
Ufuk BERBER1, Ismail YILMAZ1, Omer YILMAZ2, Aptullah HAHOLU1, Zafer KUCUKODACI1, Ferhat ATES2, Dilaver DEMIREL1
1GATA Haydarpasa Training Hospital, Department of Pathology, TURKEY
2GATA Haydarpasa Training Hospital, Department of Urology, Ankara, TURKEY
Keywords: Prostate cancer, GSTM1, GSTP1, GSTT1, Polymorphism
We analysed glutathione S-transferase M1, T1, and P1 gene polymorphisms in a case control study to asses their susceptibility to prostate cancer in Turkish population. Polymorphisms were determined by PCR-based methods in 115 control subjects and 115 prostate cancer patients. The frequencies of polymorphisms were compared between patients and controls by logistic regression analysis. Possible associations of genetic profiles with respect to the Gleason score and patient age were also investigated. Besides GSTT1 null genotype has slightly increased prostate cancer risk (odds ratio(OR) = 1.50, 95% confidence interval (CI), 0.85-2.66), its association with prostate cancer risk was statistically significant among smokers (OR = 3.20, 95%CI, 1.06-9.70). GSTP1 Val/Val genotype was more common in cancer patients (OR = 1.63, 95%CI, 0.61-4.37). However, the combination of GSTP1 Ile/Ile and GSTT1 null genotype was associated with a higher risk (OR = 2.67, 95%CI, 1.00-7.10). Our results suggest that GSTT1 null genotype may modify prostate cancer risk among cigarette smokers seperately, and in combination with GSTP1 Ile/Ile genotype, irrespective of the smoking habit in Turkish population.
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