International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 061-071
OUR EXPERIENCE OF PATIENTS WITH SOFT TISSUE SARCOMAS TREATED BETWEEN 1990 AND 2002
İLHAN ÖZTOP1, UĞUR YILMAZ1, HASAN HAVITÇIOĞLU1, MEHMET ŞEN1, BİNNAZ DEMİRKAN1, SERMİN ÖZKAL1, IŞIL KUNDAK1, SABRİ BARUTCA1, NEZİH MEYDAN1, METİN MANİSALI1, MEHMET ALAKAVUKLAR1
Dokuz Eylül Üniversitesi Tıp Fakültesi, İç Hastalıkları ABD, Hematoloji-Onkoloji BD
Keywords: soft tissue sarcomas, treatment, prognostic factors
The aim of this study is to present our treatment and follow-up results belong to the soft tissue sarcomas which show a distinct biological behaviour despite constitue a small proportion in the adult solid tumors. The data of fifty patients who diagnosed soft tissue sarcoma and followed in our department between 1990 and 2002 were reviewed retrospectively. Twenty two patients were women and 28 were men and the mean age was 47+29. A biopsy, an incomplete excision or a complete excision were done in 4 (8%), 34 (68%) and 12 (24%) patients respectively. The most frequent primary tumour location was the extremities and two-third of them was located in distal extremities. Lung metastases were seen as the most frequent (90%) metastatic location. When the distrubution of histological type was reviewed, leomyosarcoma (24%), MFH (18%) and liposarcoma (18%) were found the most common histological types. Thirty-six patients were given first-line chemotherapy (26 of these were adjuvant, 10 were palliative). All patients who received chemotherapy had high grade tumors. Ifosfamide and doxorubicin regimen was the most frequent chemotherapy regimen given to these patients. Ten (20%) patients had taken second-line and 4 (8%) patients third-line chemotherapy. Grade 3-4 neutropenia and thrombocytopenia were seen in 11 (22%) and 2 (4%) patients respectively. In survival analysis, factors effecting survival were found as: tumor size, grade, presence or absence of residual tumor. In whole group, the 1-year and 2-year survival rates were 53% and 38% respectively. Factors effecting recurrence were found as: histological type, surgical margin positivity and location.
İLHAN ÖZTOP1, UĞUR YILMAZ1, HASAN HAVITÇIOĞLU1, MEHMET ŞEN1, BİNNAZ DEMİRKAN1, SERMİN ÖZKAL1, IŞIL KUNDAK1, SABRİ BARUTCA1, NEZİH MEYDAN1, METİN MANİSALI1, MEHMET ALAKAVUKLAR1
Dokuz Eylül Üniversitesi Tıp Fakültesi, İç Hastalıkları ABD, Hematoloji-Onkoloji BD
Keywords: soft tissue sarcomas, treatment, prognostic factors
The aim of this study is to present our treatment and follow-up results belong to the soft tissue sarcomas which show a distinct biological behaviour despite constitue a small proportion in the adult solid tumors. The data of fifty patients who diagnosed soft tissue sarcoma and followed in our department between 1990 and 2002 were reviewed retrospectively. Twenty two patients were women and 28 were men and the mean age was 47+29. A biopsy, an incomplete excision or a complete excision were done in 4 (8%), 34 (68%) and 12 (24%) patients respectively. The most frequent primary tumour location was the extremities and two-third of them was located in distal extremities. Lung metastases were seen as the most frequent (90%) metastatic location. When the distrubution of histological type was reviewed, leomyosarcoma (24%), MFH (18%) and liposarcoma (18%) were found the most common histological types. Thirty-six patients were given first-line chemotherapy (26 of these were adjuvant, 10 were palliative). All patients who received chemotherapy had high grade tumors. Ifosfamide and doxorubicin regimen was the most frequent chemotherapy regimen given to these patients. Ten (20%) patients had taken second-line and 4 (8%) patients third-line chemotherapy. Grade 3-4 neutropenia and thrombocytopenia were seen in 11 (22%) and 2 (4%) patients respectively. In survival analysis, factors effecting survival were found as: tumor size, grade, presence or absence of residual tumor. In whole group, the 1-year and 2-year survival rates were 53% and 38% respectively. Factors effecting recurrence were found as: histological type, surgical margin positivity and location.