International Journal of Hematology and Oncology 2019, Vol 29, Num 3 Page(s): 044-053
CLINICAL IMPLEMENTATION OF INTENSITY MODULATED RADIATION THERAPY IN HEAD AND NECK CANCER

GÖKHAN ÖZYİĞİT1, UĞUR SELEK1, K. S. CLİFFORD CHAO1

University Of Texas, M.D. Anderson Cancer Center, Department Radiation Oncology Houston, Texas, USA

Keywords: intensity modulated radiation therapy, head and neck cancers
Intensity modulated radiation therapy (IMRT) involves the delivery of optimized, non-uniform beam intensities to the patient. The tightly conformal doses produced by IMRT, many critical structures in close proximity to the target, and the lack of internal organ motion in the head neck region, provide potential for organ sparing and improved tumor control. The dosimetric superiority of IMRT over conventional techniques has been demonstrated. The initial results of clinical studies demonstrated reduced xerostomia and other toxicities resulting from radiation therapy. They also suggest improved tumor control, and survival rates, which needs to be verified in larger studies and longer follow-up.