International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 038-043
INTESTINAL T-CELL LYMPHOMA UNLIKE LYMPHOMA SECONDARY TO CELIAC DISEASE: A CASE OF A MIDDLE-AGED MALE
ENDER SERİN1, YÜKSEL GÜMÜRDÜLÜ1, BİROL ÖZER1, FAZİLET KAYASELÇUK1, İLHAN TUNCER1
Başkent University Faculty of Medicine, Department of Gastroenterology ADANA
Keywords: gastrointestinal t-cell lymphoma, celiac disease, epstein barr virus antibody
Gastrointestinal T-cell lymphomas are heterogeneous, but the best characterized forms are associated with celiac disease. Recent reports have described a variety of this tumor that differs from that typically seen in celiac disease, but the etiology of this form is unknown. Most patients develop intestinal T-cell lymphomas in their sixth or seventh decade, but younger individuals are also affected. T-cell lymphomas arise as ulcerated plaques or strictures in the proximal small intestine. We describe the case of a middle-aged man who had an atypical form of intestinal T-cell lymphoma in which the duodenal and jejunal mucosa was infiltrated with small T-cells. The patient tested positive for EBV IgG type antibody , negative for antiendomysial and antigliadin antibodies, and his HLA phenotype only partly matched that typically seen in individuals with celiac disease. Upper gastrointestinal endoscopy revealed nonulcerated duodenal mucosa with a fine granular texture, and abdominal computed tomography demonstrated generalized concentric thickening of the wall of the jejunum, and of the second and third sections of the duodenum. This extensive form of small intestinal T-cell lymphoma seems to be a distinct entity
ENDER SERİN1, YÜKSEL GÜMÜRDÜLÜ1, BİROL ÖZER1, FAZİLET KAYASELÇUK1, İLHAN TUNCER1
Başkent University Faculty of Medicine, Department of Gastroenterology ADANA
Keywords: gastrointestinal t-cell lymphoma, celiac disease, epstein barr virus antibody
Gastrointestinal T-cell lymphomas are heterogeneous, but the best characterized forms are associated with celiac disease. Recent reports have described a variety of this tumor that differs from that typically seen in celiac disease, but the etiology of this form is unknown. Most patients develop intestinal T-cell lymphomas in their sixth or seventh decade, but younger individuals are also affected. T-cell lymphomas arise as ulcerated plaques or strictures in the proximal small intestine. We describe the case of a middle-aged man who had an atypical form of intestinal T-cell lymphoma in which the duodenal and jejunal mucosa was infiltrated with small T-cells. The patient tested positive for EBV IgG type antibody , negative for antiendomysial and antigliadin antibodies, and his HLA phenotype only partly matched that typically seen in individuals with celiac disease. Upper gastrointestinal endoscopy revealed nonulcerated duodenal mucosa with a fine granular texture, and abdominal computed tomography demonstrated generalized concentric thickening of the wall of the jejunum, and of the second and third sections of the duodenum. This extensive form of small intestinal T-cell lymphoma seems to be a distinct entity