International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 213-219
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Albumin Infusion is not Beneficial in Hypoalbuminemic End-Stage Cancer Patients: A Matched-Pair Analysis
Abdullah BUYUKCELIK1, Ahmet DEMIRKAZIK2, Bulent YALCIN3, Mutlu DOGAN2, Halil KAVGACI4, Sahin COBAN5, Fikri ICLI2
1Acibadem University Faculty of Medicine, Department of Internal Medicine, Istanbul, TURKEY
2Ankara University Faculty of Medicine, Department of Medical Oncology, Ankara, TURKEY
3Yildirim Beyazıt University Faculty of Medicine, Department of Internal Medicine, Ankara, TURKEY
4Karadeniz Technical University Faculty of Medicine, Department of Medical Oncology, Trabzon, TURKEY
5Diskapi Yildirim Beyazit Training and Research Hospital, Department of Gastroenterology, Ankara, TURKEY
Keywords: Cancer, Hypoalbuminemia, Terminally ill cancer patient, Albumin infusion
In this retrospective study, it was aimed whether albumin infusion is benefical or not in terminally ill hospitalized hypoalbuminemic cancer patients. Between March 2000 and 31 March 2003, the medical records of 27 terminally ill hypoalbuminemic cancer patients who had albumin infusion(Albumin receiving group-ARG), were retrospectively analysed. This grup was matched (1:1) with 27 terminally ill cancer patients who had no albumin infusion (Albumin not receiving group-ANRG), according to age, sex, ECOG PS, diagnosis and the number of metastatic sites. ARG was compared with ANRG, in regard to the changes of pulse rate, blood pressure, in the levels of serum BUN, creatinin, sodium, total protein, and albumin before albumin infusion and 48 hours after albumin infusion, and documented and/or clinical infections after albumin infusion, hospitalization duration, the rate of exitus in hospital and overall survival. There was no difference in patient characteristics between two groups. Likewise, the groups were not different from each other in terms of the changes of puls rate, blood pressure, in the levels of serum BUN, creatinin, sodium, and documented and/or clinical infections after albumin infusion (p> 0.05). There was a significant increase in the levels of serum total protein and albumin in ARG (p< 0.05). The rate of exitus in hospital is not different between two groups. The median duration of hospitalization was longer in ANRG (p= 0.022). The overall survival was significantly better in ANRG (p= 0.018). Albumin infusion is not benefical in terminally ill hypoalbuminemic cancer patients. Furthermore, it was found that the survival was significantly worse in patients receiving albumin.
Abdullah BUYUKCELIK1, Ahmet DEMIRKAZIK2, Bulent YALCIN3, Mutlu DOGAN2, Halil KAVGACI4, Sahin COBAN5, Fikri ICLI2
1Acibadem University Faculty of Medicine, Department of Internal Medicine, Istanbul, TURKEY
2Ankara University Faculty of Medicine, Department of Medical Oncology, Ankara, TURKEY
3Yildirim Beyazıt University Faculty of Medicine, Department of Internal Medicine, Ankara, TURKEY
4Karadeniz Technical University Faculty of Medicine, Department of Medical Oncology, Trabzon, TURKEY
5Diskapi Yildirim Beyazit Training and Research Hospital, Department of Gastroenterology, Ankara, TURKEY
Keywords: Cancer, Hypoalbuminemia, Terminally ill cancer patient, Albumin infusion
In this retrospective study, it was aimed whether albumin infusion is benefical or not in terminally ill hospitalized hypoalbuminemic cancer patients. Between March 2000 and 31 March 2003, the medical records of 27 terminally ill hypoalbuminemic cancer patients who had albumin infusion(Albumin receiving group-ARG), were retrospectively analysed. This grup was matched (1:1) with 27 terminally ill cancer patients who had no albumin infusion (Albumin not receiving group-ANRG), according to age, sex, ECOG PS, diagnosis and the number of metastatic sites. ARG was compared with ANRG, in regard to the changes of pulse rate, blood pressure, in the levels of serum BUN, creatinin, sodium, total protein, and albumin before albumin infusion and 48 hours after albumin infusion, and documented and/or clinical infections after albumin infusion, hospitalization duration, the rate of exitus in hospital and overall survival. There was no difference in patient characteristics between two groups. Likewise, the groups were not different from each other in terms of the changes of puls rate, blood pressure, in the levels of serum BUN, creatinin, sodium, and documented and/or clinical infections after albumin infusion (p> 0.05). There was a significant increase in the levels of serum total protein and albumin in ARG (p< 0.05). The rate of exitus in hospital is not different between two groups. The median duration of hospitalization was longer in ANRG (p= 0.022). The overall survival was significantly better in ANRG (p= 0.018). Albumin infusion is not benefical in terminally ill hypoalbuminemic cancer patients. Furthermore, it was found that the survival was significantly worse in patients receiving albumin.
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