International Journal of Hematology and Oncology 2023, Vol 33, Num 4 Page(s): 156-162
C-erb-B2 (Her2/neu) Expression Rate And its Association with Clinicopathologic Parameters in Gastric Cancer

Sukru YILDIRIM1, Ozgur DANDIN2, Muzaffer DURMUS3, Ugur KARAPINAR4, Murat ASLAN5, Mehmet GOKCE6, Fadime SAHIN6

1Bursa Military Hospital, Department of Pathology, Bursa, TURKEY
2Bursa Military Hospital, Department of General Surgery, Bursa, TURKEY
3Bursa Military Hospital, Department of Plastic and Reconstructive Surgery, Bursa, TURKEY
4Bursa Military Hospital Department of Ear Nose Throat, Bursa, TURKEY
5Bursa Military Hospital, Department of Oncology, Bursa, TURKEY
6Patomer Pathology Laboratory, Bursa, TURKEY

Keywords: C-erb-B2, Gastric adenocarcinoma, Immunohistochemistry, Trastuzumab
We aimed to investigate the frequency of c-erb-B2 expression rate and its association with clinicopathological parameters in our gastric carcinoma series to make a contribution to emerging data on this oncogene. One hundred thirty-nine gastric adenocarcinoma patients underwent total gastrectomy between years 2006 and 2011 were selected to the study. C-erb-B2 expressions were determined by using immunohistochemical and/or chromogenic in situ hybridisation methods in tumor tissues. A total of 16 (11.5%) gastric adenocarcinoma cases were found positive for c-erb-B2 expression. Out of 16 positive cases, 13 had intestinal type adenocarcinomas. C-erb-B2 overexpression was significantly associated with histologic subtype (p= 0.001), and histologic tumor grade (p= 0.001). The frequency of overexpression in intestinal subtype (21.7%) was comparable with the known rates of overexpression in breast cancer. This results indicate that C-erb-B2 expression may identify a subgroup in gastric carcinoma cases which may benefit from targeted treatment modalities among Turkish population.