International Journal of Hematology and Oncology 2019, Vol 29, Num 2 Page(s): 094-098
The Role of Prohepcidin and Hepcidin in Anemia Associated with Behçet’s Disease

Mehmet DAGLI1, Sema YILMAZ2, Abdullah SIVRIKAYA3, Gulperi CELIK4

1Selcuk University, Selcuklu Faculty of Medicine, Department of Internal Medicine, Hematology Unit, Konya, TURKEY
2Selcuk University, Selcuklu Faculty of Medicine, Department of Internal Medicine, Rheumatology Unit, Konya, TURKEY
3Selcuk University, Selcuklu Faculty of Medicine, Department of Biochemistry, Konya, TURKEY
4Selcuk University, Selcuklu Faculty of Medicine, Department of Internal Medicine, Nephrology Unit, Konya, TURKEY

Keywords: Prohepcidin, Hepcidin, Anemia, Behçet’s disease
The aim of the study is to investigate the role of circulating prohepcidin and hepcidin, which are homeostatic regulators of iron metabolism and mediators of inflammation, in anemia associated with Behçet’s disease (BD) and the differential diagnosis of healthy controls. Twenty patients with BD and twenty healthy controls were included in this prospective study. Laboratory tests including complete blood count, serum prohepcidin, hepcidin, iron, total iron binding capacity (TIBC), transferrin, ferritin, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were determined. Serum prohepcidin and hepcidin levels in patients with BD were significantly higher than healthy group. In the group with BD positive correlation was determined between the values of serum prohepcidin, hepcidin, hemoglobin, total binding capacity and ferritine. Serum prohepcidin and hepcidin levels are closely associated with disease activity in patients and might play a role in the pathobiology of chronic disease anemia associated with patients with BD.