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Unusual Extramedullary Recurrence and Renal Relapse Despite Complete Chimerysm after Allografting in Ph+ ALL

Songul SEREFHANOGLU¹, Hakan GOKER¹, Dilek E. BAYDAR², Aysegul UNER², Mustafa ARICI³, Ibrahım C. HAZNEDAROGLU¹, Yahya BUYUKASIK¹, Nılgun SAYINALP¹, Salıh AKSU¹, Osman I. OZCEBE<sup>1

1</sup>Hacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ankara, TURKEY
²Hacettepe University Faculty of Medicine, Department of Pathology, Ankara, TURKEY
³Hacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Nephrology, Ankara, TURKEY

Keywords: ALL, Renal relapse, Allogeneic stem cell transplantation, Complete chimerism

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Extramedullary recurrences with or without bone marrow involvement are reported in up to a half of leukemic relapses after bone marrow transplantation. Extramedullary relapse of acute lymphoblastic leukemia (ALL) in the kidney after allogeneic stem cell transplantation (allo-SCT) is rare. We herein, report an additional case with extramedullary recurrences and renal relapse after first-allografting for Ph+-acute lymphoblastic leukemia. He had no evidence of leukemia in his marrow demonstrating 98% full-donor chimerism while he had ALL relapse in his kidney.

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