International Journal of Hematology and Oncology 2022, Vol 32, Num 4 Page(s): 051-053
5-Flourouracil–Induced Encephalopathy in Parkinson’s disease

Taner KORKMAZ1, Selcuk SEBER1, Gul BASARAN1, P. Fulden YUMUK1, Faysal DANE1, Muharrem KOCAR1, Ferhat TELLI1, N. Serdar TURHAL1

Marmara Medical University, Department of Medical Oncology, Istanbul, TURKEY

Keywords: Parkinson’s disease, 5-Flourouracil, Rectum cancer, Encephalopathy
A 59 year-old male with Parkinson’s disease developed encephalopathy during adjuvant treatment of rectal cancer. Acute neurotoxicity related to high dose 5-Flourouracil infusion is well described, but encephalopathy with low dose bolus 5-Flourouracil is rare. The advanced Parkinson’s disease patients may be more prone to hyperammonemia associated encephalopathy caused by 5-Flourouracil . The prompt recognition of the symptoms is key to diagnosis and treatment.