International Journal of Hematology and Oncology 2020, Vol 30, Num 2 Page(s): 192-195
Childhood Acute Lymphoblastic Leukemia with Near-Tetraplody And t(12; 21) (p13;q22) Translocation: A Case Report

Mutlu KARKUCAK1, Tahsin YAKUT1, Birol BAYTAN2, Tuna GULTEN1, A. Meral GUNES2

1Uludag University Faculty of Medicine, Department of Medical Genetics , Bursa, TURKEY
2Uludag University Faculty of Medicine, Department of Pediatric Hematology, Bursa, TURKEY

Keywords: Childhood acute lymphoblastic leukemia, Near-Tetraploidy , t(12;21)
Fluroscent in situ hybridization analysis indicated presence of t(12;21)(p13;q22) translocation and near-tetraploidy in a case who 11-year-old boy and diagnosed with B precursor acute lymphoblastic leukemia (ALL). Although, some studies suggest good prognostic effect of translocation t(12;21) (p13;q22), there were very little data regarding the prognostic effect of Near- tetraploidy. Here we discussed the prognostic relevance of both t(12;21)(p13;q22) translocation and near tetraplody in Pre-B ALL.