International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 160-165
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Topical Ankaferd Bloodstopper in the Management of Critical Bleedings due to Hemorrhagic Diathesis
Mehmet TURGUT1, Ferda TUTKUN2, Nükhet CELEBI2, Mehtap MUGLALI2, İbrahim C. HAZNEDAROGLU3, Hakan GOKER3
1Samsun 19 Mayıs University Faculty of Medicine, Department of Hematology, Samsun, TURKEY
2Samsun 19 Mayıs University, Faculty of Dentistry, Samsun, TURKEY
3Hacettepe University Faculty of Medicine, Department of Hematology, Ankara, TURKEY
Keywords: Ankaferd, Bleeding, Hemostasis, Hemorrhagic diathesis
Ankaferd BloodStopper® (ABS) is an herbal extract which has been used historically as a haemostatic agent in traditional Turkish medicine. ABS comprises of standardized mixture of herbs Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum and Urtica dioica. Basic effect mechanism of ABS is the formation of an encapsulated protein web which represents the focus points for the vital erythrocyte masses. The haemostatic effects have been demonstrated by in vitro and in vivo studies. The usage of ABS as a hemostatic agent in external hemorrhages and in dental treatment in humans constitutes the first hints on ABS’s safety and efficacy in humans. A phase I randomized, double-blinded, cross-over, placebo controlled clinical study in healthy volunteers indicated the safety of ABS. The aim of this report is to depict hemostatic effects of ABS in critical bleedings due to hemorrhagic diathesis, refractory to conventional measures in distinct clinical settings.
Mehmet TURGUT1, Ferda TUTKUN2, Nükhet CELEBI2, Mehtap MUGLALI2, İbrahim C. HAZNEDAROGLU3, Hakan GOKER3
1Samsun 19 Mayıs University Faculty of Medicine, Department of Hematology, Samsun, TURKEY
2Samsun 19 Mayıs University, Faculty of Dentistry, Samsun, TURKEY
3Hacettepe University Faculty of Medicine, Department of Hematology, Ankara, TURKEY
Keywords: Ankaferd, Bleeding, Hemostasis, Hemorrhagic diathesis
Ankaferd BloodStopper® (ABS) is an herbal extract which has been used historically as a haemostatic agent in traditional Turkish medicine. ABS comprises of standardized mixture of herbs Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum and Urtica dioica. Basic effect mechanism of ABS is the formation of an encapsulated protein web which represents the focus points for the vital erythrocyte masses. The haemostatic effects have been demonstrated by in vitro and in vivo studies. The usage of ABS as a hemostatic agent in external hemorrhages and in dental treatment in humans constitutes the first hints on ABS’s safety and efficacy in humans. A phase I randomized, double-blinded, cross-over, placebo controlled clinical study in healthy volunteers indicated the safety of ABS. The aim of this report is to depict hemostatic effects of ABS in critical bleedings due to hemorrhagic diathesis, refractory to conventional measures in distinct clinical settings.
| Back | Table of Contents | Turkish Abstract | PDF | Mail to Author | |