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Hypersensitivity to Procarbazine and Severe RSV Pneumonia in a Child with Hodgkin’s Lymphoma

Dilek INCE ¹, Duygu OLMEZ², Tolga F. KOROGLU³, Arzu B. HOCAOGLU², Secil A. CAMLAR⁴, Kamer M. UYSAL¹, Nevin UZUNER², Nur OLGUN<sup>1

1</sup>Dokuz Eylul University Institute of Oncology, Department of Pediatric Oncology, Izmir, Turkey
²Dokuz Eylul University, Faculty of Medicine, Department of Pediatric Allergy, Izmir, Turkey
³Dokuz Eylul University, Faculty of Medicine, Department of Pediatrics, Pediatric Intensive Care Unit, Izmir, Turkey
⁴Dokuz Eylul University, Faculty of Medicine, Department of Pediatrics, Izmir, Turkey

Keywords: Procarbazine, Chemotherapy, Hypersensitivity, Skin reaction, Pulmonary toxicity, Treatment, Child, Respiratory

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Herein we report respiratory syncytial virus (RSV) pneumonia in a child who had hypersensitivity to procarbazine. Urticarial plaques, maculopapular rash occurred in a child with Hodgkin’s lymphoma while receiving procarbazine. Clinical improvement was achieved by withdrawal of procarbazine, administration of corticosteroids, diphenhydramine. After receiving the next course with bleomycin containing chemotherapy, RSV pneumonia developed which required prolonged mechanical ventilation and was treated with oral ribavirin. Hypersensitivity to procarbazine can be a life treating condition. Omitting procarbazine may be necessary. Respiratory syncytial virus pneumonia in the setting of both immunsupression and procarbazine / bleomycin toxicity may have a more serious course.

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