International Journal of Hematology and Oncology 2020, Vol 30, Num 2 Page(s): 052-056
Isolated Bone Metastases in Early Stage Endometrial Adenocarcinoma: A Case Report and Review of the Literature

Mevlut KURT1, Saadettin KILICKAP2, Sercan AKSOY2, Mustafa ERMAN2, Gokhan GEDIKOGLU3, Alev TURKER2

1Turkiye Yuksek Ihtisas Teaching and Research Hospital, Department of Gastroenterology, Ankara, TURKEY
2Hacettepe University Institute of Oncology, Department of Medical Oncology, Ankara, TURKEY
3Hacettepe University Faculty of Medicine, Department of Pathology, Ankara, TURKEY

Keywords: Endometrial carcinoma, Bone metastasis, Treatment
Isolated skeletal metastasis of endometrial carcinoma is very unusual. We report here a 62-year-old woman diagnosed as FIGO stage IC, grade I, endometrial carcinoma who was found to have isolated femur and tibia metastases just after completing local radiotherapy. Incisional biopsy revealed metastatic adenocarcinoma. Following radiotherapy, medroxyprogesterone acetate and zoledronic acid was given. After a month, spontaneous right proximal femur fracture occurred and new bone metastasis was detected. Local radiotherapy and six cycles of paclitaxel and carboplatin were given; however, during a 3-year follow-up, bone metastases progressed. We review the endometrial carcinoma with bone metastasis in literature.