International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 229-234
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Expression of the Fragile Histidine Triad Gene in Laryngeal Carcinoma
Ediz TUTAR1, Erkan KARATAS2, Tekin BAGLAM2
1GaziantepUniversity, Faculty of Medicine, Department of Pathology, Gaziantep, TURKEY
2GaziantepUniversity, Faculty of Medicine, Department of Otolaryngology– Head and Neck Surgery, Gaziantep, TURKEY
Keywords: Fragile Histidine Triad Protein, Laryngeal neoplasms, Metastasis
The aim of this study was to investigate Fragile Histidine Triad Gene (FHIT) expression in laryngeal squamous cell carcinoma. The paraffin embedded tissue blocks of 64 laryngeal squamous cell carcinoma specimens were enrolled in the study. FHIT expression was detected by an immunohistochemical method. Rabbit polyclonal antibody was used for immunohistochemical study. FHIT expression was low in 40.6% of patients and high in 59.6% of patients. Results were compared with clinicopathological variables. There was a significant correlation between high FHIT expression and lymph node metastasis (p<0.05). There was no significant correlation between FHIT expression and age, histological grade, perineural invasion and vascular invasion. In conclusion, FHIT may be accepted to play a role in laryngeal squamous cell carcinoma tumorigenesis as a tumor suppressor gene.
Ediz TUTAR1, Erkan KARATAS2, Tekin BAGLAM2
1GaziantepUniversity, Faculty of Medicine, Department of Pathology, Gaziantep, TURKEY
2GaziantepUniversity, Faculty of Medicine, Department of Otolaryngology– Head and Neck Surgery, Gaziantep, TURKEY
Keywords: Fragile Histidine Triad Protein, Laryngeal neoplasms, Metastasis
The aim of this study was to investigate Fragile Histidine Triad Gene (FHIT) expression in laryngeal squamous cell carcinoma. The paraffin embedded tissue blocks of 64 laryngeal squamous cell carcinoma specimens were enrolled in the study. FHIT expression was detected by an immunohistochemical method. Rabbit polyclonal antibody was used for immunohistochemical study. FHIT expression was low in 40.6% of patients and high in 59.6% of patients. Results were compared with clinicopathological variables. There was a significant correlation between high FHIT expression and lymph node metastasis (p<0.05). There was no significant correlation between FHIT expression and age, histological grade, perineural invasion and vascular invasion. In conclusion, FHIT may be accepted to play a role in laryngeal squamous cell carcinoma tumorigenesis as a tumor suppressor gene.
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