International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 096-102
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Prognostic Factors Affecting the Clinical Course of non-Hodgkin’s Lymphomas
Yavuz BEYAZIT1, Murat KEKILLI1, Tugrul PURNAK2, Hakan GOKER3, Salih AKSU3, İbrahim C. HAZNEDAROGLU3, Osman I. OZCEBE3
1Turkiye Yuksek Ihtisas Training and Research Hospital, Department of Gastroenterology, Ankara, TURKEY
2Ankara Numune Training and Research Hospital, Department of Gastroenterology, Ankara, TURKEY
3Hacettepe University Faculty of Medicine, Department of Hematology, Ankara, TURKEY
Keywords: NHL, Clinical characteristics, Prognostic factors, IPI
Non-Hodgkin’s lymphoma (NHL) includes lymphoproliferative malignant diseases with a wide variety of clinicopathologic appearances. The aim of our study was to analyse the critical prognostic factors that effect clinical picture in NHL patients. In this study, we retrospectively evaluated the effects of the clinical characteristics, International Prognostic Index (IPI) parameters (age, stage, performance status, extranodal sites, and serum lactate dehydrogenase), and other prognostic parameters (bulky disease, grade of disease, “B” symptoms, and ß-2 microglobulin levels) on overall survival (OS) and disease-free survival (DFS) in NHL patients who have been diagnosed in our department. Stage of the patients was not related with OS and DFS. But higher grade and IPI levels were found to be independent prognostic factors that predict OS. According to clinical and laboratory parameters, only age and bulky disease were found to be an independent risk factor that predict OS. In conclusion, our results suggest that, using only the stage and/or grade of the disease does not completely correlate with the prognosis. Stage and grade could be significant indicators, if they are evaluated along with other prognostic factors.
Yavuz BEYAZIT1, Murat KEKILLI1, Tugrul PURNAK2, Hakan GOKER3, Salih AKSU3, İbrahim C. HAZNEDAROGLU3, Osman I. OZCEBE3
1Turkiye Yuksek Ihtisas Training and Research Hospital, Department of Gastroenterology, Ankara, TURKEY
2Ankara Numune Training and Research Hospital, Department of Gastroenterology, Ankara, TURKEY
3Hacettepe University Faculty of Medicine, Department of Hematology, Ankara, TURKEY
Keywords: NHL, Clinical characteristics, Prognostic factors, IPI
Non-Hodgkin’s lymphoma (NHL) includes lymphoproliferative malignant diseases with a wide variety of clinicopathologic appearances. The aim of our study was to analyse the critical prognostic factors that effect clinical picture in NHL patients. In this study, we retrospectively evaluated the effects of the clinical characteristics, International Prognostic Index (IPI) parameters (age, stage, performance status, extranodal sites, and serum lactate dehydrogenase), and other prognostic parameters (bulky disease, grade of disease, “B” symptoms, and ß-2 microglobulin levels) on overall survival (OS) and disease-free survival (DFS) in NHL patients who have been diagnosed in our department. Stage of the patients was not related with OS and DFS. But higher grade and IPI levels were found to be independent prognostic factors that predict OS. According to clinical and laboratory parameters, only age and bulky disease were found to be an independent risk factor that predict OS. In conclusion, our results suggest that, using only the stage and/or grade of the disease does not completely correlate with the prognosis. Stage and grade could be significant indicators, if they are evaluated along with other prognostic factors.
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