International Journal of Hematology and Oncology 2019, Vol 29, Num 2 Page(s): 018-028
THE TREATMENT RESULTS IN PATIENTS IRRADIATED WITH THE DIAGNOSIS OF HIGH GRADE BRAIN TUMOR: RETROSPECTIVE EVALUATION

Evrim TUNÇ1, Diclehan ÜNSAL1, Ayşen S. ÖZTÜRK1, Petek TATER1, Müge AKMANSU1, Yücel PAK1

Gazi Üniversitesi Tıp Fakültesi Radyasyon Onkolojisi Anabilim Dalı, ANKARA

Keywords: Brain tumor, High grade, Radiotherapy, Prognosis
The properties and the efficacy of the treatment was applied in our patients with high grade brain tumor. Between 1998 and 2003, 80 patients with high grade brain tumor were treated with radiotherapy. Forty-eight patients were referred to radiotherapy after total excision, 32 patients after subtotal excision or biopsy. Radiotherapy was applied in conventional fractionation. The overall survival was 10.00±0.54 months in patients irradiated after subtotal excision and 15.27±4.24 months in patients irradiated after total excision (p= 0.0106). In univariate analysis age (p= 0.0198), histopathological diagnosis (p=0.0001) and the extent of operation (p= 0.0279) were found to be statistically significant, and Karnofsky Performance Status (KPS) (p= 0.0518) was found to have a trend to significance. In multivariate analysis, KPS (p= 0.0040), histopathological diagnosis (p=0.0001) and the extent of operation (p=0.0344) were found to be statistically significant variables effective on survival. A significant correlation was detected between greater tumor size (¡İ 5 cm) and older age in patients with glioblastoma multiforme. According to our retrospective analysis, KPS, histopathological diagnosis and the extent of operation were determined to be important prognostic factors in correlation to the literature.