International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 042-044
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Type-I Hypersensitivity Reaction Secondary to Deferasirox Intake
Pamir ISIK1, Nese YARALI1, Ali BAY1, Serap OZMEN2, Bahattin TUNC1
1Dr. Sami Ulus Education and Research Hospital, Department of Pediatric Hematology, Ankara, TURKEY
2Gaziantep University Faculty of Medicine, Department of Pediatric Hematology, Gaziantep, TURKEY
3Dr. Sami Ulus Education and Research Hospital, Department of Pediatric Allergy, Ankara, TURKEY
Keywords: Deferasirox, Skin rash, Type-I hypersensitivity reaction
Deferasirox is a new generation tridentate iron chelator. We report a ten-year old ß-thalassaemic boy, who had type-I hypersensitivity reaction due to deferasirox intake. At the seventh day of deferasirox treatment, he admitted to our clinic with the complaints of pruritic skin rash which began from the neck that spreaded throughout the body. After the termination of deferasirox treatment, the rash didn't recur. When deferasirox was restarted, similar skin rashes reappeared immediately. The skin prick, intradermal and patch tests and oral deferasirox provocation test were performed after 1 year, and the former reaction did not appear. Here in we showed when the defasirox was used first time even it caused some allergic reactions, however during the time period it can be used again due to the possibility of development of immune tolerance.
Pamir ISIK1, Nese YARALI1, Ali BAY1, Serap OZMEN2, Bahattin TUNC1
1Dr. Sami Ulus Education and Research Hospital, Department of Pediatric Hematology, Ankara, TURKEY
2Gaziantep University Faculty of Medicine, Department of Pediatric Hematology, Gaziantep, TURKEY
3Dr. Sami Ulus Education and Research Hospital, Department of Pediatric Allergy, Ankara, TURKEY
Keywords: Deferasirox, Skin rash, Type-I hypersensitivity reaction
Deferasirox is a new generation tridentate iron chelator. We report a ten-year old ß-thalassaemic boy, who had type-I hypersensitivity reaction due to deferasirox intake. At the seventh day of deferasirox treatment, he admitted to our clinic with the complaints of pruritic skin rash which began from the neck that spreaded throughout the body. After the termination of deferasirox treatment, the rash didn't recur. When deferasirox was restarted, similar skin rashes reappeared immediately. The skin prick, intradermal and patch tests and oral deferasirox provocation test were performed after 1 year, and the former reaction did not appear. Here in we showed when the defasirox was used first time even it caused some allergic reactions, however during the time period it can be used again due to the possibility of development of immune tolerance.
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