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Richter's Transformation; the Cause of Fever of Unknown Origin in a Case with Chronic Lymphocytic Leukemia

Behice KURTARAN¹, Semra PAYDAS², Sinan YAVUZ², Aslıhan CANDEVİR<sup>1

1</sup>Cukurova University Faculty of Medicine, Department of Infectious Disease, Adana, TURKEY
²Cukurova University Faculty of Medicine, Department of Medical Oncology, Adana, TURKEY

Keywords: Chronic lymphocytic leukemia (CLL), Fever of unkonown origin (FUO), Richter transformation (RT)

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Chronic lymphocytic leukemia (CLL) is the most common leukemia in many countries. Infections are the most common causes of morbidity and mortality; lymphoid cell dysfunction and neutropenia associated with chemotherapy are main predisposing conditions for infection. For this reason infectious conditions must be excluded in a case with CLL and fever. Richter’s transformation (RT) is a kind of lymphoma that is a rare condition in CLL cases Fever of unknown origin is a rare finding in Richter’s transformation (RT) but it has been reported as anecdotal reports. Here a case with RT as the cause of fever in a case with CLL was reported and literature was reviewed.

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