International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 082-087
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Justification for the Use of CA 125 Levels After Cardiac Surgery
R. Oktay PEKER1, Tülay T PEKER2, Ercan VAROL3, Mehmet ÖZAYDIN3, Şenol GÜLMEN1, Osman GÖKALP4, Savaş KAYA5, Şahin KAPAN1, Doğan ERDOĞAN3, Recep SÜTÇÜ6, Ahmet ÖCAL1
1Süleyman Demirel University Faculty of Medicine, Department of Cardiovascular Surgery
2Süleyman Demirel University Faculty of Medicine, Department of Anaesthesiology and Reanimation
3Süleyman Demirel University Faculty of Medicine, Department of Cardiology, Isparta
4Dicle University Faculty of Medicine, Department of Pharmacology
5Dicle University Faculty of Medicine, Department of Medical Biology and Genetics, Diyarbakır
6Süleyman Demirel University Faculty of Medicine, Department of Biochemistry, Isparta, TURKEY
Keywords: Tumor marker CA 125, Cardiac surgery, Cardiopulmonary by-pass
CA 125, a tumor marker has been found to be elevated in malign conditions as well as in some benign conditions like heart failure. Cardiac surgery has been shown to cause a systemic inflammatory response. In this study, we investigated alterations in serum levels of CA 125 during cardiac surgery with cardiopulmonary by-pass. Thirty nine patients with a mean age of 54.7 years who underwent either coronary bypass surgery or valvular heart surgery were prospectively recruited to the study. We measured plasma levels of CA 125 preoperatively and on postoperative days 1 and 7. Comparing with preoperative values, CA 125 levels were similar on postoperative day 1 (5.26 [6.89] U/ml vs 5.74 [4.54] U/ml) but elevated significantly on postoperative day 7 (42.1 [34] U/ml, p< 0.0001) (data in median interquantile range). CA 125 levels were found to be elevated after cardiac surgery. The elevations are more in patients undergoing valvular heart surgery than coronary bypass graft surgery. Although CA 125 can be considered a reliable tumor marker in the diagnosis and follow up of patients with malignant diseases, the presence of a recent cardiac surgery with cardiopulmonary bypass must be taken into account when asking for the cause of elevated CA 125 plasma level.
R. Oktay PEKER1, Tülay T PEKER2, Ercan VAROL3, Mehmet ÖZAYDIN3, Şenol GÜLMEN1, Osman GÖKALP4, Savaş KAYA5, Şahin KAPAN1, Doğan ERDOĞAN3, Recep SÜTÇÜ6, Ahmet ÖCAL1
1Süleyman Demirel University Faculty of Medicine, Department of Cardiovascular Surgery
2Süleyman Demirel University Faculty of Medicine, Department of Anaesthesiology and Reanimation
3Süleyman Demirel University Faculty of Medicine, Department of Cardiology, Isparta
4Dicle University Faculty of Medicine, Department of Pharmacology
5Dicle University Faculty of Medicine, Department of Medical Biology and Genetics, Diyarbakır
6Süleyman Demirel University Faculty of Medicine, Department of Biochemistry, Isparta, TURKEY
Keywords: Tumor marker CA 125, Cardiac surgery, Cardiopulmonary by-pass
CA 125, a tumor marker has been found to be elevated in malign conditions as well as in some benign conditions like heart failure. Cardiac surgery has been shown to cause a systemic inflammatory response. In this study, we investigated alterations in serum levels of CA 125 during cardiac surgery with cardiopulmonary by-pass. Thirty nine patients with a mean age of 54.7 years who underwent either coronary bypass surgery or valvular heart surgery were prospectively recruited to the study. We measured plasma levels of CA 125 preoperatively and on postoperative days 1 and 7. Comparing with preoperative values, CA 125 levels were similar on postoperative day 1 (5.26 [6.89] U/ml vs 5.74 [4.54] U/ml) but elevated significantly on postoperative day 7 (42.1 [34] U/ml, p< 0.0001) (data in median interquantile range). CA 125 levels were found to be elevated after cardiac surgery. The elevations are more in patients undergoing valvular heart surgery than coronary bypass graft surgery. Although CA 125 can be considered a reliable tumor marker in the diagnosis and follow up of patients with malignant diseases, the presence of a recent cardiac surgery with cardiopulmonary bypass must be taken into account when asking for the cause of elevated CA 125 plasma level.
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