International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 042-047
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Decreased NKG2D Expression on Natural Killer Cells in Gastric Cancer Patients
Bülent KARAGÖZ1, Oğuz BİLGİ1, E. Gökhan KANDEMİR1, Özkan SAYAN2, Alev A. ERİKÇİ1, Alpaslan ÖZGÜN1, Bahiddin YILMAZ1, Orhan TÜRKEN1, Ahmet ÖZTÜRK2
1Gülhane Military Medical Academy, Haydarpaşa Training Hospital, Department of Internal Medicine, Division of Medical Oncology, İSTANBUL
2Gülhane Military Medical Academy, Haydarpaşa Training Hospital, Department of Internal Medicine, Division of Hematology, İSTANBUL
Keywords: NKG2D, NK cells, Immunity, Gastric cancer, KIR
NKG2D is an activating receptor of natural killer (NK) cells. NKG2D expression have not been studied on NK cells of gastric cancer patients so far. Therefore, we aimed to investigate NKG2D of NK and T cells in peripheral blood of patients with gastric cancer.
Twelve chemotherapy and radiotherapy naive patients with gastric cancer and 25 age-matched healty volunteers were enrolled in this study. NKG2D expressions on NK and T cells were evaluated by three color flow cytometry. The hematological and flow cytometric parameters were compared between cancer patients and healthy subjects. Hemoglobin and hematocrite values were decreased in patients compared with those of controls. Other hematological parameters, T cells (CD56-CD3+ cells) and NK cells (CD56+CD3- cells) were not different between groups. The percentage of NKG2D positivity in NK cells was significantly lower in gastric cancer patients than healthy subjects (84.4% ± 9.5% vs 90.2% ± 8.2%; p= 0.02, respectively), whereas NKG2D positive T cells were similar.
NKG2D expression is decreased on NK cells in gastric cancer patients. Further studies which explore the biological significance of lower NKG2D expression and its putative anti-tumor role in cancer patients should be established.
Bülent KARAGÖZ1, Oğuz BİLGİ1, E. Gökhan KANDEMİR1, Özkan SAYAN2, Alev A. ERİKÇİ1, Alpaslan ÖZGÜN1, Bahiddin YILMAZ1, Orhan TÜRKEN1, Ahmet ÖZTÜRK2
1Gülhane Military Medical Academy, Haydarpaşa Training Hospital, Department of Internal Medicine, Division of Medical Oncology, İSTANBUL
2Gülhane Military Medical Academy, Haydarpaşa Training Hospital, Department of Internal Medicine, Division of Hematology, İSTANBUL
Keywords: NKG2D, NK cells, Immunity, Gastric cancer, KIR
NKG2D is an activating receptor of natural killer (NK) cells. NKG2D expression have not been studied on NK cells of gastric cancer patients so far. Therefore, we aimed to investigate NKG2D of NK and T cells in peripheral blood of patients with gastric cancer.
Twelve chemotherapy and radiotherapy naive patients with gastric cancer and 25 age-matched healty volunteers were enrolled in this study. NKG2D expressions on NK and T cells were evaluated by three color flow cytometry. The hematological and flow cytometric parameters were compared between cancer patients and healthy subjects. Hemoglobin and hematocrite values were decreased in patients compared with those of controls. Other hematological parameters, T cells (CD56-CD3+ cells) and NK cells (CD56+CD3- cells) were not different between groups. The percentage of NKG2D positivity in NK cells was significantly lower in gastric cancer patients than healthy subjects (84.4% ± 9.5% vs 90.2% ± 8.2%; p= 0.02, respectively), whereas NKG2D positive T cells were similar.
NKG2D expression is decreased on NK cells in gastric cancer patients. Further studies which explore the biological significance of lower NKG2D expression and its putative anti-tumor role in cancer patients should be established.
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