International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 153-160
EVALUATION OF TOTAL SKIN ELECTRON BEAM THERAPY AND TREATMENT MORBIDITY IN MYCOSIS FUNGOIDES
KAAN OYSUL1, BAHAR DİRİCAN1, MURAT BEYZADEOĞLU1, SERDAR SÜRENKÖK1
Department of Radiation Oncology, Gülhane Military Medical Academy, ANKARA
Keywords: mycosis fungoides, skin radiomorbidity, total skin electron therapy
The purpose of this study is to report in vivo dosimetric measurements, clinical results and late sequelae of the total skin electron beam therapy (TSEBT). Between March 1997 and March 2004, 18 mycosis fungoides patients have been treated at Gulhane Military Medical School, Department of Radiation Oncology. Patients with T2-3N0M0B0 disease have received 28Gy TSEBT in 7 fractions. The median follow-up time was 20.5 months from the completion of TSEBT. At 3 months after TSEBT, complete response was established in 14 patients (77.8%) and partial response in 4 patients (22.2%). Late skin injury parameters of atrophy, pigmentation change, hair loss, telangiectasia, and ulceration evaluated according to RTOG/EORTC late skin injury scale were grade 1 in 3 patients (16.7%), grade 2 in 8 patients in (44.4%), grade 3 in 6 patients (33.3%) and grade 4 in 1 patient(5.6%). In conclusion, we can say that the modified translational technique is an easy technique capable of covering the transverse dimensions of the patients resulting in early remission of the lesions and lowering of the underdosage areas, however the high fraction size we used is probably the main reason of increased late skin morbidity, although more deeply situated tissues are spared.
KAAN OYSUL1, BAHAR DİRİCAN1, MURAT BEYZADEOĞLU1, SERDAR SÜRENKÖK1
Department of Radiation Oncology, Gülhane Military Medical Academy, ANKARA
Keywords: mycosis fungoides, skin radiomorbidity, total skin electron therapy
The purpose of this study is to report in vivo dosimetric measurements, clinical results and late sequelae of the total skin electron beam therapy (TSEBT). Between March 1997 and March 2004, 18 mycosis fungoides patients have been treated at Gulhane Military Medical School, Department of Radiation Oncology. Patients with T2-3N0M0B0 disease have received 28Gy TSEBT in 7 fractions. The median follow-up time was 20.5 months from the completion of TSEBT. At 3 months after TSEBT, complete response was established in 14 patients (77.8%) and partial response in 4 patients (22.2%). Late skin injury parameters of atrophy, pigmentation change, hair loss, telangiectasia, and ulceration evaluated according to RTOG/EORTC late skin injury scale were grade 1 in 3 patients (16.7%), grade 2 in 8 patients in (44.4%), grade 3 in 6 patients (33.3%) and grade 4 in 1 patient(5.6%). In conclusion, we can say that the modified translational technique is an easy technique capable of covering the transverse dimensions of the patients resulting in early remission of the lesions and lowering of the underdosage areas, however the high fraction size we used is probably the main reason of increased late skin morbidity, although more deeply situated tissues are spared.