International Journal of Hematology and Oncology 2023, Vol 33, Num 4 Page(s): 166-169
Rectal Squamous Cell Carcinoma: A Case Report and Review of the Literature

Yüksel KÜÇÜKZEYBEK1, Gürbüz GÖRÜMLÜ1, Ercüment CENGİZ1, Burçak KARACA1, Çiğdem ERTEN1, M. Kemal GÜL1, Fatih TEKİN2, A. Can KAZANDI3, Bülent KARABULUT1

1Ege Üniversitesi Tıp Fakültesi Medikal Onkoloji Bilim Dalı, İZMİR
2Ege Üniversitesi Tıp Fakültesi Gastroenteroloji Bilim Dalı, İZMİR
3Ege Üniversitesi Tıp Fakültesi Dermatoloji Ana Bilim Dalı, İZMİR

Keywords: Rectal cancer, Squamous cell carcinoma
Colorectal squamous cell carcinoma is an extremely rare tumor, comprising 0.01-0.025% of all colorectal cancers. A 55 years-old woman complaining of rectal bleeding was admitted to the hospital. An ulcerovegetan mass was seen in rectosigmoidoscopy and biopsies were taken. Histopathological examination revealed diagnosis as epidermoid cell carcinoma of rectum. Hypodense nodules were seen in different segments of liver in computerized tomography. After she was admitted to our hospital, rectosigmoidoscopy was repeated and biopsies were taken from ulcerovegetan mass in the rectum. The diagnosis was confirmed as squamous cell carcinoma. Paliative pelvic radiotherapy was delivered because of pain complain. The combination regimen including uracil-tegafur and carboplatin was administered because of the lack of standart chemotherapy regimens in this type cancer. After 3 cycles of chemotherapy, stable disease was defined in the radiological evaluation and her ECOG performance status improved. Therefore, we planned to continue with the same chemotherapy regimen. We detected radiologically progressive disease after six cycles of chemotherapy. We decided to report this case because of the rarity of squamous cell carcinoma of the rectum and the absence of standart chemotherapy regimen.